Results 61 to 70 of about 18,450 (284)

A comprehensive, multi-level investigation of the implementation of a novel digital substance misuse intervention, Breaking Free Online: conceptualising implementation processes within services using the MRC framework and health psychology theory.

Frontiers in Public Health, 2015
Background: Medical Research Council (MRC: Craig et al., 2008) guidelines outline the importance of a cycle of continual development, feasibility testing, outcomes evaluation and implementation analysis when creating and evaluating complex interventions.
Stephanie Dugdale, Martha Dalton
doaj   +1 more source

A Deep Learning Framework for Intelligent Fault Diagnosis Using AutoML-CNN and Image-like Data Fusion

Machines, 2023
Intelligent fault diagnosis (IFD) is essential for preventative maintenance (PM) in Industry 4.0. Data-driven approaches have been widely accepted for IFD in smart manufacturing, and various deep learning (DL) models have been developed for different ...
Yan Gao, Chengzhang Chai, Haijiang Li, Weiqi Fu   +3 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Implementation of a complex intervention to improve care for patients whose situations are clinically uncertain in hospital settings: A multi-method study using normalisation process theory

PLoS ONE, 2020
Purpose To examine the use of Normalisation Process Theory (NPT) to establish if, and in what ways, the AMBER care bundle can be successfully normalised into acute hospital practice, and to identify necessary modifications to optimise its implementation.
Halle Johnson, Emel Yorganci, Catherine J. Evans, Stephen Barclay, Fliss E. M. Murtagh, Deokhee Yi, Wei Gao, Elizabeth L. Sampson, Joanne Droney, Morag Farquhar, Jonathan Koffman, Alessandra Solari   +11 more
doaj   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Left Ventricular Hypertrabeculation (LVHT) in Athletes: A Negligible Finding?

Medicina
Left ventricular hypertrabeculation (LVHT) used to be a rare phenotypic trait. With advances in diagnostic imaging techniques, LVHT is being recognised in an increasing number of people.
Rokas Jagminas, Rokas Šerpytis, Pranas Šerpytis, Sigita Glaveckaitė   +3 more
doaj   +1 more source

Decision-Making Behaviour Evolution Among Pork Supply and Demand Subjects Under Normalisation of COVID-19 Prevention and Control: A Case Study in China

Frontiers in Public Health, 2022
Affected by the coronavirus disease 2019 (COVID-19), there were short-term uncertainties in China's live pig industry supply chain. Due to the insufficient supply of pork, the price of pork rose from 33.21 yuan/kg at the end of 2019 to 37.46 yuan/kg in ...
Li Ma, Yidi Wang, Yun Teng, Yun Teng
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Evaluating the Impact of a Paediatric Burn Club for Children and Families Using Group Concept Mapping

European Burn Journal, 2023
Access to burn camps and clubs is cited as an essential element for children following a burn injury. In the Northern Regional Burns Service, this takes the form of a club run by a multidisciplinary team, offering residential camps and family day trips ...
Emma L. Hodgkinson, Alison McKenzie, Louise Johnson   +2 more
doaj   +1 more source