Results 71 to 80 of about 155,801 (328)

Using the method of normalisation for mapping group marks to individual marks: some observations

Assessment & Evaluation in Higher Education, 2020
The method of normalisation combined with peer ratings is utilised to provide the solution to the biased rating problem of mapping group work marks to individual marks.
Mehdi Chowdhury
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

A Review of Theory and Practice in Scientometrics [PDF]

, 2015
Scientometrics is the study of the quantitative aspects of the process of science as a communication system. It is centrally, but not only, concerned with the analysis of citations in the academic literature.
Leydesdorff, Loet, Mingers, John
core   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

SimArray: a user-friendly and user-configurable microarray design tool

BMC Bioinformatics, 2006
Background Microarrays were first developed to assess gene expression but are now also used to map protein-binding sites and to assess allelic variation between individuals.
Meadows Lisa A, Fischer Bettina, Russell Roslin R, Auburn Richard P, Sevillano Matilla Santiago, Russell Steven   +5 more
doaj   +1 more source

A Deep Learning Framework for Intelligent Fault Diagnosis Using AutoML-CNN and Image-like Data Fusion

Machines, 2023
Intelligent fault diagnosis (IFD) is essential for preventative maintenance (PM) in Industry 4.0. Data-driven approaches have been widely accepted for IFD in smart manufacturing, and various deep learning (DL) models have been developed for different ...
Yan Gao, Chengzhang Chai, Haijiang Li, Weiqi Fu   +3 more
doaj   +1 more source

A systematic evaluation of single cell RNA-seq analysis pipelines

Nature Communications, 2019
The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a large variety of experimental and computational pipelines for which best practices have not yet been established.
B. Vieth, Swati Parekh, C. Ziegenhain, W. Enard, Ines Hellmann   +4 more
semanticscholar   +1 more source

Three practical field normalised alternative indicator formulae for research evaluation [PDF]

Journal of Informetrics, 2017
Although altmetrics and other web-based alternative indicators are now commonplace in publishers' websites, they can be difficult for research evaluators to use because of the time or expense of the data, the need to benchmark in order to assess their values, the high proportion of zeros in some alternative indicators, and the time taken to calculate ...
openaire   +4 more sources