Results 71 to 80 of about 1,823,674 (334)

On (Normalised) Discounted Cumulative Gain as an Off-Policy Evaluation Metric for Top-$n$ Recommendation [PDF]

arXiv, 2023
Approaches to recommendation are typically evaluated in one of two ways: (1) via a (simulated) online experiment, often seen as the gold standard, or (2) via some offline evaluation procedure, where the goal is to approximate the outcome of an online experiment. Several offline evaluation metrics have been adopted in the literature, inspired by ranking
arxiv  

Double Machine Learning based Program Evaluation under Unconfoundedness [PDF]

, 2020
This paper reviews, applies and extends recently proposed methods based on Double Machine Learning (DML) with a focus on program evaluation under unconfoundedness. DML based methods leverage flexible prediction models to adjust for confounding variables in the estimation of (i) standard average effects, (ii) different forms of heterogeneous effects ...
arxiv   +1 more source

From theory to 'measurement' in complex interventions: methodological lessons from the development of an e-health normalisation instrument [PDF]

, 2012
<b>Background</b> Although empirical and theoretical understanding of processes of implementation in health care is advancing, translation of theory into structured measures that capture the complex interplay between interventions ...
A Rogers, A Webster, C Jensen, C May, C May, C May, C May, C May, C May, Carl R May, Catherine O’Donnell, D Forster, DRP Oliver, E Murray, E Murray, Elizabeth Murray, EM Rogers, EMC Murray, F Mair, FMC Mair, Frances S Mair, G Eysenbach, GLF Elwyn, H Zetterburg, J Gunn, J Presseau, J Turner, JD Linton, JJ Francis, LBP Gask, M Eccles, M Hechter, Mowatt, MP Gagnon, P Legris, P Wilson, R Grol, R Snyder-Halpern, RPTM Grol, S Lieberson, S Michie, S Treweek, S Wilkes, T Finch, T Greenhalgh, Tracy L Finch, WEK Lehman   +46 more
core   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Multisite reproducibility and test-retest reliability of the T1w/T2w-ratio: A comparison of processing methods

NeuroImage, 2021
Background: The ratio of T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging (MRI) images is often used as a proxy measure of cortical myelin.
Stener Nerland, Kjetil N. Jørgensen, Wibeke Nordhøy, Ivan I. Maximov, Robin A.B. Bugge, Lars T. Westlye, Ole A. Andreassen, Oliver M. Geier, Ingrid Agartz   +8 more
doaj  

SimArray: a user-friendly and user-configurable microarray design tool

BMC Bioinformatics, 2006
Background Microarrays were first developed to assess gene expression but are now also used to map protein-binding sites and to assess allelic variation between individuals.
Meadows Lisa A, Fischer Bettina, Russell Roslin R, Auburn Richard P, Sevillano Matilla Santiago, Russell Steven   +5 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

What drives adoption of a computerised, multifaceted quality improvement intervention for cardiovascular disease management in primary healthcare settings? A mixed methods analysis using normalisation process theory

Implementation Science, 2018
Background A computerised, multifaceted quality improvement (QI) intervention for cardiovascular disease (CVD) management in Australian primary healthcare was evaluated in a cluster randomised controlled trial.
Bindu Patel, Tim Usherwood, Mark Harris, Anushka Patel, Kathryn Panaretto, Nicholas Zwar, David Peiris   +6 more
doaj   +1 more source

A Deep Learning Framework for Intelligent Fault Diagnosis Using AutoML-CNN and Image-like Data Fusion

Machines, 2023
Intelligent fault diagnosis (IFD) is essential for preventative maintenance (PM) in Industry 4.0. Data-driven approaches have been widely accepted for IFD in smart manufacturing, and various deep learning (DL) models have been developed for different ...
Yan Gao, Chengzhang Chai, Haijiang Li, Weiqi Fu   +3 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source