Results 81 to 90 of about 155,801 (328)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

A comprehensive, multi-level investigation of the implementation of a novel digital substance misuse intervention, Breaking Free Online: conceptualising implementation processes within services using the MRC framework and health psychology theory.

Frontiers in Public Health, 2015
Background: Medical Research Council (MRC: Craig et al., 2008) guidelines outline the importance of a cycle of continual development, feasibility testing, outcomes evaluation and implementation analysis when creating and evaluating complex interventions.
Stephanie Dugdale, Martha Dalton
doaj   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Temporal expression normalisation in natural language texts [PDF]

, 2012
Automatic annotation of temporal expressions is a research challenge of great interest in the field of information extraction. In this report, I describe a novel rule-based architecture, built on top of a pre-existing system, which is able to normalise ...
Filannino, Michele
core   +1 more source

Multi Voxel Descriptor for 3D Texture Retrieval

Emitter: International Journal of Engineering Technology, 2016
In this paper, we present a new feature descriptors  which exploit voxels for 3D textured retrieval system when models vary either by geometric shape or texture or both. First, we perform pose normalisation to modify arbitrary 3D models  in order to have
Hero Yudo Martono
doaj   +3 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Leptonic Decays of Heavy Quarks on the Lattice [PDF]

, 1997
The status of lattice calculations of heavy-light decay constants and of the $B$ parameter $B_B$ is reviewed. After describing the lattice approach to heavy quark systems, the main results are discussed, with special emphasis on the systematic errors in ...
Alexandrou C., Ali A., Bali G. S., Ball P., Bernard C., Bernard C. W., Bhattacharya T., Bhattacharya T., Bitar K. M., Bitar K. M., Boucaud Ph., Buras A. J., Capstick S., Collins S., DeGrand T. A., Duncan A., El-Khadra A. X., Flynn J. M., Gérard J.-M., Güsken S., Hartmut Wittig, Hashimoto S., Herrlich S., Hwang D. S., Kogut J., Lepage G. P., Marinari E., Michael C., Narison S., Neubert M., Neubert M., Particle Data Group (R. M. Barnett et al., Thacker B. A., Voloshin M. B., Wilson K. G., Zeitnitz C.   +35 more
core   +2 more sources

Evaluating the Impact of a Paediatric Burn Club for Children and Families Using Group Concept Mapping

European Burn Journal, 2023
Access to burn camps and clubs is cited as an essential element for children following a burn injury. In the Northern Regional Burns Service, this takes the form of a club run by a multidisciplinary team, offering residential camps and family day trips ...
Emma L. Hodgkinson, Alison McKenzie, Louise Johnson   +2 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Development and formative evaluation of the e-Health implementation toolkit [PDF]

, 2010
<b>Background</b> The use of Information and Communication Technology (ICT) or e-Health is seen as essential for a modern, cost-effective health service. However, there are well documented problems with implementation of e-Health initiatives,
AL Kitson, C May, C May, Carl May, CD Helfrich, CM DesRoches, DC Balfour, Department of Health, DS Thompson, EA Akl, Elizabeth Murray, F Mair, Frances Mair, H Oh, House of Commons Health Committee, J Hendy, JD Linton, M Cross, M Dobbins, M Petticrew, MP Gagnon, National Audit Office, NC Campbell, NHS Connecting for Health, P Craig, R Lilley, T Greenhalgh   +26 more
core   +4 more sources