Results 111 to 120 of about 7,188 (249)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Co‐Producing Personalised Discharge Planning: Developing a Toolkit to Improve Caregiver Involvement in Hospital Transitions

Health Expectations
Background Informal caregivers are often expected to support patients transitioning from hospital to home and yet are routinely overlooked in discharge planning.
Kathryn McEwan, Tom Sanders, Sue Carr, Peter Van Der Graaf, Susan Jones, Maria Raisa Jessica Aquino, Mitchell James Hogg, Rakhshanda Hameed, Frank Lai, Christina Cooper, Sebastian Potthoff   +10 more
doaj   +1 more source

Investigating community pharmacists’ perceptions of delivering chlamydia screening to young people: a qualitative study using normalisation process theory to understand professional practice

, 2022
Lara Ahmaro, Laura Lindsey, Simon Forrest, Cate Whittlesea   +3 more
openalex   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Telehealth in practice: using Normalisation Process Theory to bridge the translational gap [PDF]

Primary Care Respiratory Journal, 2011
Deborah, Morrison, Frances S, Mair
openaire   +2 more sources

Reducing restrictive measures in complex long-term care for people with intellectual disabilities: Implementation interventions through the lens of normalisation process theory [PDF]

, 2022
Esther Bisschops, J.C. de Schipper, Baukje Schippers, P.J.C.M. Embregts, Carlo Schuengel   +4 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A mixed methods evaluation of the breastfeeding memory aide CHINS

Maternal and Child Nutrition
Breastfeeding rates remain persistently low in the United Kingdom (UK) despite wide‐scale rollout of UNICEF Baby Friendly Initiative training and accreditation. More must be done to ensure breastfeeding practitioners can provide effective support.
Lynette Shotton, Tracy Collins, Reinie Cordier, Fadzai Chikwava, Mary Steen   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Co-designing organisational improvements and interventions to increase inpatient activity in four stroke units in England: a mixed-methods process evaluation using normalisation process theory [PDF]

, 2021
David Clarke, Karolina Gombert, Stephanie Honey, Geoffrey Cloud, Ruth Harris, Alastair Macdonald, Christopher McKevitt, Glenn Robert, Fiona Jones   +8 more
openalex   +1 more source