Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Making multiple comparisons easy: a decision tree and visual statistics guide for data with more than two groups. [PDF]
Gurski CJ, Dittel BN.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Non-Glycemic Clinical Data for Type 2 Diabetes Detection in Mexican Adults: A Comparative Analysis of Atherogenic Indices, Statistical Transformations, and Machine Learning Algorithms. [PDF]
Guerrero-Flores MH +8 more
europepmc +1 more source
Evaluating the FEV1/FVC ratio in the lower range of normality as a marker of worse clinical outcomes in asthmatic subjects without airway obstruction [PDF]
Cintia Fernanda Bertagni Mingotti +6 more
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Intracellular calcium release activates carotid body afferents by fentanyl. [PDF]
Peng YJ +5 more
europepmc +1 more source
Deviation from Normality and Sharpe Ratio Behavior: A Brief Simulation Study
Hayette Gatfaoui
openalex +1 more source
Testing the Root-N Asymptotic Normality for the GMM and M Estimators [PDF]
Yuya Sasaki, Yulong Wang
openalex
Consistency and Asymptotic Normality of the Maximum Likelihood Estimator in Generalized Linear Models [PDF]
Ludwig Fahrmeir, Heinz Kaufmann
openalex +1 more source

