Results 171 to 180 of about 526,031 (267)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Assessing the robustness of normality tests under varying skewness and kurtosis: a practical checklist for public health researchers. [PDF]

BMC Med Res Methodol
Kamath A, Poojari S, Varsha K.
europepmc   +1 more source

Imposed quasi-normality in covariance structure analysis [PDF]

, 1993
Ruud H. Koning, Heinz Neudecker, Tom Wansbeek   +2 more
openalex  

Extracellular matrix between normality and pathology: techniques and methodologies

, 2006
Sefora Valdevit, Mariangela Rutigliani, Francesco Boccardo, C. Campisi, Ezio Fulcheri   +4 more
openalex   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Clinical simulation as an effective teaching model in the Special Needs Dentistry course. [PDF]

BMC Med Educ
Mellinas-Martínez I, Pecci-Lloret MP, Pecci-Lloret MR, Adánez-Martínez MG, Guerrero-Gironés J.   +4 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A novel composite biomarker score for the identification of cognitive impairment in patients with heart failure: a pilot study. [PDF]

Biomarkers
Hoyer-Kimura C, Palmer J, Gopalan R, Doyle K, Frye J, Juneman E, Irwin K, Galdamez-Avila A, Carrillo K, Lizzette Cruz S, Schrag C, Oskouie S, Kalya A, Bedoya A, Konhilas JP, Ashton NJ, Ryan L, Sweitzer NK, Hay M.   +18 more
europepmc   +1 more source

Asymptotic Normality of Sample Quantiles for $m$-Dependent Processes [PDF]

, 1968
Pranab Kumar Sen
openalex   +1 more source