Results 101 to 110 of about 1,117,675 (339)

Pengaruh Gaya Kepemimpinan Dan Motivasi Kerja Terhadap Kinerja Manajer [PDF]

open access: yes, 2012
This research is conducted to prove the leadership influence and working motivation through the manager's performances with functional manager and general manager on manufacturing company in Palembang as an example.
Natalia, Priska
core  

Test Spaces for Normal Spaces [PDF]

open access: yesProceedings of the American Mathematical Society, 1962
Let Q be a class of topological spaces. For X in Q, let dim X denote the dimension of X defined in terms of finite open coverings. If Q is the class of all normal spaces, then the dimension of spaces X in Q is characterized by the following theorem [2, p. 212]: dimX^n if, and only if, given any closed subset C of X, any continuous mapping of C into the
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

A new approach to the Box-Cox transformation

open access: yesFrontiers in Applied Mathematics and Statistics, 2015
We propose a new methodology to estimate λ, the parameter of the Box-Cox transformation, as well as an alternative method to determine plausible values for it.
Jorge Iván eVélez   +2 more
doaj   +1 more source

Skewness and kurtosis as locally best invariant tests of normality

open access: yes, 2006
Consider testing normality against a one-parameter family of univariate distributions containing the normal distribution as the boundary, e.g., the family of $t$-distributions or an infinitely divisible family with finite variance.
Kuriki, Satoshi   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

A Simple Empirical Likelihood Ratio Test for Normality Based on the Moment Constraints of a Half-Normal Distribution

open access: yesJournal of Probability and Statistics, 2018
A simple and efficient empirical likelihood ratio (ELR) test for normality based on moment constraints of the half-normal distribution was developed.
C. S. Marange, Y. Qin
doaj   +1 more source

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