Results 171 to 180 of about 8,410,400 (313)

Leukocyte Profiles in Breeding Female and Pup Southern Elephant Seals (<i>Mirounga leonina</i>) in Relation to Lactation and Body Condition. [PDF]

Animals (Basel)
Descayrac P, Bichet C, Badaut J, Picard B, Guinet C, López-Ramon J, Lizana V, Gilbert C.   +7 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Long-term outcomes of orthokeratology in eyes with myopic regression after photorefractive keratectomy (PRK): a retrospective clinical study of 12 eyes. [PDF]

BMC Ophthalmol
Rotondi A, Stratta C, Colandrea C, Frisani M.   +3 more
europepmc   +1 more source

Test

Tes
Test
core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Interobserver reliability and temporal variability of artificial intelligence chatbots in Kennedy-classified removable partial denture design: A cross-sectional analysis. [PDF]

J Indian Prosthodont Soc
El Naggar SM, Esmat AM, Helal EG, Khalil MF, Gouda AM.   +4 more
europepmc   +1 more source

MVJB: RATS procedure to perform Multivariate Jarque-Bera normality test

Computes a multivariate version of the Jarque-Bera test for normality. Note that there are more sophisticated versions of this (for instance, Doornik and Hansen, "An Omnibus Test for Univariate and Multivariate Normality"). This just transforms the input
Tom Doan
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The Normal Hip Score Following Hip Fracture: Preliminary Validation of a Single-Item Patient-Reported Outcome Measure. [PDF]

J Clin Med
Lim BZH, Leitch GC, Williamson TR, Duckworth AD, Clement ND.   +4 more
europepmc   +1 more source