Results 121 to 130 of about 165,617 (285)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Geology, Ecology, and LandscapesMangrove ecosystems along Pakistan’s coastline provide critical ecological services, including coastal protection, carbon sequestration, and biodiversity support, but face increasing threats from sea-level rise, salinity intrusion, and reduced freshwater
Tofeeq Ahmad +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Geodesy and CartographyRemote sensing techniques and GIS were used in this study to monitor urban growth in Karbala Governorate, Iraq. A compiled database was created from available Multi-temporal Landsat (TM, ETM+ and OLI) data from 2000 to 2018.
Nabaa Falih Naser +2 more
doaj +1 more source
, 2018 Wetlands are one of the most important ecosystems on the Earth and play a critical role in regulating regional climate, preventing floods, and reducing flood severity.
Zeyu Liang +4 more
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Combining proximal and remote sensing to assess ‘Calatina’ olive water status
Frontiers in Plant ScienceDeveloping an efficient and sustainable precision irrigation strategy is crucial in contemporary agriculture. This study aimed to combine proximal and remote sensing techniques to show the benefits of using both monitoring methods, simultaneously ...
Alessandro Carella +5 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Discover GeoscienceThe 21st century is very much affected by climate change due to the increase of urban sprawl and the population explosion, causing anthropogenic activities and industrialisation, which are contributing to global warming and affecting climate change. Thus,
Meenakshi Sharma +5 more
doaj +1 more source