Results 71 to 80 of about 242,788 (269)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Glacier boundary extraction and spatiotemporal variation analysis in Geladandong region [PDF]

PeerJ
Glaciers, as sensitive indicators of global climate change, play a crucial role in influencing the global water cycle, sea level rise, and ecosystem dynamics.
Haotian Liu, Dongchuan Wang, Tingrong Li, Ang Yue, Shuang Zhao, Lihui Zhang, Kai Ye, Haotian Zhang, Shuaizheng Ji   +8 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessing the Impacts of the 2009/2010 Drought on Vegetation Indices, Normalized Difference Water Index, and Land Surface Temperature in Southwestern China

, 2017
Droughts are projected to increase in severity and frequency on both regional and global scales. Despite the increasing occurrence and intensity of the 2009/2010 drought in southwestern China, the impacts of drought on vegetation in this region remain ...
Xiaoqiang Zhang, Y. Yamaguchi, Fei Li, B. He, Yaning Chen   +4 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Identification of Surface Water Storing Sites Using Topographic Wetness Index (TWI) and Normalized Difference Vegetation Index (NDVI)

Journal of Natural Resources and Development, 2018
Ethiopia is endowed with water and has a high runoff generation area compared to many countries, but the total stored water only goes up to approximately 36BCM.
Ethiopia Bisrat, Belete Berhanu
doaj   +1 more source

A NEW MULTI-SPECTRAL THRESHOLD NORMALIZED DIFFERENCE WATER INDEX (MST-NDWI) WATER EXTRACTION METHOD – A CASE STUDY IN YANHE WATERSHED

, 2018
. Accurate remote sensing water extraction is one of the primary tasks of watershed ecological environment study. Since the Yanhe water system has typical characteristics of a small water volume and narrow river channel, which leads to the difficulty for
Y. Zhou, H. Zhao, H. Hao, Chen Wang
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Project Geo-spatial Technology for Tracking Climate Variability and its Effects A case Study Lake Magadi and Environs, Kenya

African Journal on Land Policy and Geospatial Sciences
Contexte and Background: This study explores the impact of climate variability on environmental sustainability in Lake Magadi, Kenya, using geospatial technology.
Pauline Wamalwa, Elijah Kiarie, Paul Mwangi   +2 more
doaj   +1 more source