Results 71 to 80 of about 165,617 (285)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Satellite- based drought indicators for supporting sustainable water management [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Over the past decades, pressures have placed the basin’s ecological and hydrological systems at serious risk.  The Azraq , located in eastern Jordan, is an essential ecosystem reliant on groundwater, which is facing growing ...
A.H. Mohammad, M. Ghanem, P.A. De La Hera-rica, A.A. Al Rowwad, K. Shatanawi   +4 more
doaj   +1 more source

Glacier boundary extraction and spatiotemporal variation analysis in Geladandong region [PDF]

PeerJ
Glaciers, as sensitive indicators of global climate change, play a crucial role in influencing the global water cycle, sea level rise, and ecosystem dynamics.
Haotian Liu, Dongchuan Wang, Tingrong Li, Ang Yue, Shuang Zhao, Lihui Zhang, Kai Ye, Haotian Zhang, Shuaizheng Ji   +8 more
doaj   +2 more sources

Mapping Fluctuations of Hispar Glacier, Karakoram, using Normalized Difference Snow Index (NDSI) and Normalized Difference Principal Component Snow Index (NDSPCSI)

, 2021
Investigation of the fluctuations in the snow-covered area of the major glaciers of the Karakoram range is essential for proper water resource management in Pakistan, since its glaciers are responding differently to the ...
Nausheen Mazhar, Dania Amjad, Kanwal Javid, Rumana Siddiqui, Muhammad Ameer Nawaz, Zaynah Sohail Butt.
core   +2 more sources

Identifikasi Sebaran Spasial Genangan Banjir di Kota Pontianak Menggunakan Metode Normalized Difference Water Index [PDF]

, 2023
Salah satu bencana yang sering terjadi di daerah perkotaan saat ini adalah banjir, bencana alam berupa timbulnya genangan air yang menggenangi suatu daerah dalam jangka waktu tertentu yang menimbulkan dampak kerusakan harta benda serta kehilangan nyawa ...
Putra, Yoga Satria, Adriat, Riza, Yudistira, Angga Irfandi   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Normalized Difference Water Index, 2015-2018

This data layer is an individual GeoTIFF files with a resolution of 10 meters.A Normalized Difference Water Index (NDWI) is an indicator of open water on the landscape.
Johnson, Kris
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

PEMETAAN DAERAH RAWAN BANJIR MENGGUNAKAN PENGINDERAAN JAUH DENGAN METODE NORMALIZED DIFFERENCE VEGETATION INDEX, NORMALIZED DIFFERENCE WATER INDEX DAN SIMPLE ADDITIVE WEIGHTING ( STUDI KASUS : KOTA BENGKULU )

, 2020
Kota Bengkulu merupakan salah satu daerah yang terancam bencana banjir, dikarenakan kota Bengkulu berada pada elevasi antara 0 – 16 m dpl dengan 70% topografi datar dan 30 % berbukit kecil dan rawa.
HERNOZA, FRANKY, Susilo, Boko, Erlansari, Aan   +2 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source