Results 91 to 100 of about 330,644 (260)
Evaluation of bleeding risk in patients with renal impairment treated with Fondaparinux (Arixtra)
Journal of Applied Hematology, 2016 Background: Fondaparinux (Arixtra) a synthetic pentasaccharide that causes an antithrombin III-mediated selective inhibition of factor Xa. The clearance of fondaparinux reduces in patients with renal impairment, and there are no dosage adjustments ...
Hend H Metwali +6 more
doaj +1 more source
Star Formation History and Chemical Evolution of the Sextans Dwarf Spheroidal Galaxy
, 2009 We present the star formation history and chemical evolution of the Sextans dSph dwarf galaxy as a function of galactocentric distance. We derive these from the $VI$ photometry of stars in the $42' \times 28'$ field using the SMART model developed by Yuk
Carrea +27 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Scaling of the diffusion coefficient on the normal form remainder in doubly resonant domains
, 2008 To appear in the proceedings of the international workshop on the dynamics of celestial bodies, Litohoro, Greece, July 2008 (in honor of Prof. John Hadjidemetriou)
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journal of Health Economics and Outcomes Research, 2016 # Background Patients developing acute kidney injury (AKI) during critical illness or major surgery are at risk for renal sequelae such as costly and invasive acute renal replacement therapy (RRT) and chronic dialysis (CD).
Louise Perrault +5 more
doaj +1 more source
On the quantitative estimates of the remainder in normal forms
, 2002 We consider an analytic Hamiltonian system with three degrees of freedom and having a family of periodic orbits with a transition stability complex instability. We reduce the Hamiltonian to a normal form around a transition periodic orbit and we obtain H = Z^r + R^r.
Ollé Torner, Mercè +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Non-stationary extreme models and a climatic application [PDF]
Nonlinear Processes in Geophysics, 2007 In this paper, we study extreme values of non-stationary climatic phenomena. In the usually considered stationary case, the modelling of extremes is only based on the behaviour of the tails of the distribution of the remainder of the data set. In the non-
M. Nogaj, S. Parey, D. Dacunha-Castelle
doaj
2036 Extracellular matrix as a novel approach to glioma therapy
Journal of Clinical and Translational Science, 2018 OBJECTIVES/SPECIFIC AIMS: Gliomas are the most lethal and common primary tumor type in the central nervous system across all age groups; affected adults have a life expectancy of just 14 months.
Mark H. Murdock +5 more
doaj +1 more source