Results 51 to 60 of about 330,644 (260)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Carbon dioxide and climate impulse response functions for the computation of greenhouse gas metrics: a multi-model analysis [PDF]

Atmospheric Chemistry and Physics, 2013
The responses of carbon dioxide (CO2) and other climate variables to an emission pulse of CO2 into the atmosphere are often used to compute the Global Warming Potential (GWP) and Global Temperature change Potential (GTP), to characterize the response ...
F. Joos, R. Roth, J. S. Fuglestvedt, G. P. Peters, I. G. Enting, W. von Bloh, V. Brovkin, E. J. Burke, M. Eby, N. R. Edwards, T. Friedrich, T. L. Frölicher, P. R. Halloran, P. B. Holden, C. Jones, T. Kleinen, F. T. Mackenzie, K. Matsumoto, M. Meinshausen, G.-K. Plattner, A. Reisinger, J. Segschneider, G. Shaffer, M. Steinacher, K. Strassmann, K. Tanaka, A. Timmermann, A. J. Weaver   +27 more
doaj   +1 more source

Second Order Approximations for Slightly Trimmed Sums [PDF]

, 2011
We investigate the second order asymptotic behavior of trimmed sums $T_n=\frac 1n \sum_{i=\kn+1}^{n-\mn}\xin$, where $\kn$, $\mn$ are sequences of integers, $0\le \kn < n-\mn \le n$, such that $\min(\kn, \mn) \to \infty$, as $\nty$, the $\xin$'s denote ...
Gribkova, N. V., Helmers, R.
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications

BMC Ophthalmology, 2010
Background Microvascular complications, including retinopathy and nephropathy are seen with type 1 diabetes. It is unknown whether functional changes in aqueous humor flow or intraocular pressure (IOP) develop in parallel with these complications.
Lane James T, Larson LuAnn, Fan Shan, Stoner Julie A, Margalit Eyal, Toris Carol B   +5 more
doaj   +1 more source

Accurate modelling of the low-order secondary resonances in the spin-orbit problem

, 2019
We provide an analytical approximation to the dynamics in each of the three most important low order secondary resonances (1:1, 2:1, and 3:1) bifurcating from the synchronous primary resonance in the gravitational spin-orbit problem.
Celletti, Alessandra, Efthymiopoulos, Christos, Gkolias, Ioannis, Pucacco, Giuseppe   +3 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Optimal GQPC Codes over the Finite Field F_q

Mathematics
This paper presents the algebraic structure of generalized quasi-polycyclic (GQPC) codes, which is a generalization of the right quasi-polycyclic (QPC) and generalized quasi-cyclic (GQC) codes over a finite field Fq.
Kundan Suxena, Om Prakash, Indibar Debnath, Patrick Solé   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source