Results 61 to 70 of about 330,644 (260)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Spatial variation of iron abundance in the high speed solar wind, 1972 to 1976 [PDF]

open access: yes, 1983
The Fe/H ratios in the peaks of high speed streams (HSS) during the decline of Solar Cycle 20 and the following minimum (October 1972-December 1976) were analyzed.
Bame, S. J.   +2 more
core   +1 more source

The zeta function on the critical line: Numerical evidence for moments and random matrix theory models

open access: yes, 2011
Results of extensive computations of moments of the Riemann zeta function on the critical line are presented. Calculated values are compared with predictions motivated by random matrix theory.
Hiary, Ghaith A., Odlyzko, Andrew M.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Entropy of chaotic eigenstates [PDF]

open access: yes, 2010
These notes present a recent approach to study the high-frequency eigenstates of the Laplacian on compact Riemannian manifolds of negative sectional curvature. The main result is a lower bound on the Kolmogorov-Sinai entropy of the semiclassical measures
Nonnenmacher, Stéphane
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome

open access: yesFrontiers in Immunology, 2017
IntroductionPostoperative cognitive decline (PCD) can affect in excess of 10% of surgical patients and can be considerably higher with risk factors including advanced age, perioperative infection, and metabolic conditions such as obesity and insulin ...
Xiaomei Feng   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Poisson brackets, quasi-states and symplectic integrators [PDF]

open access: yes, 2009
This paper is a fusion of a survey and a research article. We focus on certain rigidity phenomena in function spaces associated to a symplectic manifold.
Entov, Michael   +2 more
core  

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