Results 31 to 40 of about 809,605 (268)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Journal of King Saud University: Engineering Sciences, 1999 The incompressible turbulent reattaching flow over a 2-D backward facing step with different length porous floor segments was solved numerically using the finite element numerical method.
Bassam A.K. Abu-Hijleh
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Bulletin of Mathematical SciencesIn this paper, we consider the following Schrödinger equation with perturbations of Choquard terms: −Δu−λu=|u|4u+μ(Iα∗|u|p)|u|p−2u,x∈ℝ3,∫ℝ3u2dx=c, where [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] is the Riesz ...
Peng Jin, Heng Yang, Xin’ao Zhou
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Normalized solutions for nonlinear Schrödinger systems with critical exponents
Advanced Nonlinear StudiesIn this paper, we consider the following nonlocal Schrödinger system−a+b∫R3|∇u1|2dxΔu1=λ1u1+μ1|u1|p1−2u1+βr1|u1|r1−2u1|u2|r2,−a+b∫R3|∇u2|2dxΔu2=λ2u2+μ2|u2|p2−2u2+βr2|u1|r1|u2|r2−2u2,∫R3|u1|2dx=c1,∫R3|u2|2dx=c2.
Hu Jiaqing, Mao Anmin
doaj +1 more source
Pinching Theorems for Statistical Submanifolds in Sasaki-Like Statistical Space Forms
Entropy, 2018 In this paper, we obtain the upper bounds for the normalized δ -Casorati curvatures and generalized normalized δ -Casorati curvatures for statistical submanifolds in Sasaki-like statistical manifolds with constant curvature. Further,
Ali H. Alkhaldi +3 more
doaj +1 more source
Energy Reports, 2021 To select the optimum methods, such criteria like reservoir heterogeneity, reservoir pressure, reservoir temperature, crude oil type API (American Petroleum Institute), and brine salinity.
Zhenzhen Wei +5 more
doaj +1 more source
QUASI–PERIODIC RESPONSE SOLUTIONS AT NORMAL–INTERNAL RESONANCES [PDF]
EQUADIFF 2003, 2005 In the conservative dynamics of certain quasi-periodically forced oscillators, normal-internal resonances are considered in a bifurcational setting. The unforced system is a one degree of freedom oscillator, under forcing the system becomes a skew-product flow with a quasi-periodic motion on an $n$-dimensional torus as driving ...
Broer, H. W. +4 more
openaire +4 more sources