Results 41 to 50 of about 809,605 (268)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Normalized solutions to nonautonomous Kirchhoff equation

open access: yesCommunications in Analysis and Mechanics
<p>In this paper, we studied the existence of normalized solutions to the following Kirchhoff equation with a perturbation:</p><p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ \left\{ \begin{aligned} &amp;-\left(a+b\int _{\mathbb{R}^{N}}\left | \nabla u \right|^{2} dx\right)\Delta u+\lambda u =
Xin Qiu, Zeng Qi Ou, Ying Lv
openaire   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Normalized solutions of Schrödinger equations involving Moser-Trudinger critical growth

open access: yesAdvances in Nonlinear Analysis
In this article, we are concerned with the nonlinear Schrödinger equation −Δu+λu=μ∣u∣p−2u+f(u),inR2,-\Delta u+\lambda u=\mu {| u| }^{p-2}u+f\left(u),\hspace{1em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{2}, having prescribed ...
Li Gui-Dong, Zhang Jianjun
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Numerical Solution of Nonlinear Fredholm Integrodifferential Equations by Hybrid of Block-Pulse Functions and Normalized Bernstein Polynomials

open access: yesAbstract and Applied Analysis, 2013
A numerical method for solving nonlinear Fredholm integrodifferential equations is proposed. The method is based on hybrid functions approximate. The properties of hybrid of block pulse functions and orthonormal Bernstein polynomials are presented and ...
S. H. Behiry
doaj   +1 more source

Normal solutions of linear programs [PDF]

open access: yes, 1984
The author introduces the definition of normal solution to a linear program, which is an exact solution with some least norm property if the linear program is solvable, otherwise an approximate solution with some least norm property also. By considering normal solutions we are led to (i) iterative successive overrelaxation (SOR) methods capable of ...
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The existence of ground state normalized solution for mass supercritical modified Kirchhoff equation

open access: yesResults in Applied Mathematics
In this paper, we focus on the existence of ground state solution with prescribed L2-norm for the following modified Kirchhoff problem: −a+b∫RN|∇u|2dxΔu−uΔ(u2)−λu=|u|p−2u,x∈RN,where N=2,3, a,b>0 are constants, p∈4+4N,2∗, 2∗=6 if N=3, and 2∗=+∞ if N=2. By
Zhongxiang Wang, Cai Chang
doaj   +1 more source

Regularity of solutions of the parabolic normalized p-Laplace equation

open access: yesAdvances in Nonlinear Analysis, 2018
The parabolic normalized p-Laplace equation is studied. We prove that a viscosity solution has a time derivative in the sense of Sobolev belonging locally to L2{L^{2}}.
Høeg Fredrik Arbo, Lindqvist Peter
doaj   +1 more source

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