Results 251 to 260 of about 1,794,286 (406)

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

open access: yesAdvanced Science, EarlyView.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis   +7 more
wiley   +1 more source

Characterizing the heterogeneity of neurodegenerative diseases through EEG normative modeling. [PDF]

open access: yesNPJ Parkinsons Dis
Tabbal J   +12 more
europepmc   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

open access: yesAdvanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li   +11 more
wiley   +1 more source

Vermicular Eutectic Multi‐Principal Element Alloy with Exceptional Strength and Ductility

open access: yesAdvanced Science, EarlyView.
Eutectic multi‐principal element alloys (EMPEAs) typically exhibit rod‐like or lamellar microstructures, constraining further mechanical improvements. This study introduces a novel (AlCrFe2)65Ni35 EMPEA with a unique vermicular microstructure, achieving unprecedented strength‐ductility synergy.
Liufei Huang   +11 more
wiley   +1 more source

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