Results 301 to 310 of about 1,575,044 (341)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Ethnocentric perceptions, impacts and influences of problematic alcohol use in a global community sample: a mixed-methods study. [PDF]

BMJ Public Health
Chakkera H, Butterfield R, Sardana S, Mukkatira A, Unnikrishnan B, Rai S, Appachu K, Kundranda R, Michlig GJ.   +8 more
europepmc   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Testing gender differences in psychological adjustment among early adolescents though a multigroup analysis of latent profiles. [PDF]

Sci Rep
Álvarez-Voces M, Villar P, Almón-Pazos K, Romero E.   +3 more
europepmc   +1 more source

Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection. [PDF]

Hum Brain Mapp
Muir MT, Noll K, Prinsloo S, Michener H, Traylor JI, Kumar VA, Ene CI, Ferguson S, Liu HL, Weinberg JS, Lang F, Taylor BA, Forkel SJ, Prabhu SS.   +13 more
europepmc   +1 more source

Normative values of ankle strength and its importance for rehabilitation and return to activity: A cross-sectional study. [PDF]

World J Orthop
da Fonseca LF, Jeyaraman M, Jeyaraman N, Inojossa TR, Maciel ES, de Cesar Netto C, Mansur NS, Astur DC.   +7 more
europepmc   +1 more source

"What standard should we set?": A qualitative study of rehabilitation professionals' perspectives on rehabilitation needs after traumatic injuries. [PDF]

J Rehabil Med
Howe EI, Søberg HL, Røe C, Løvstad M, Andelic N.   +4 more
europepmc   +1 more source

Exploring the Efficacy of the Occupational Therapy-Fundamental Motor Skills Training (OT-FMST) Protocol on Functional Performance in Children With Autism Spectrum Disorder. [PDF]

Cureus
Jain JG, Sharma RK, Bhardwaj S, Irem S, Dwivedi A.   +4 more
europepmc   +1 more source

Normative Data for a Multi-Domain Concussion Assessment in the Female Community Sport of Ladies Gaelic Football. [PDF]

Sports (Basel)
Leahy R, Rochfort KD, Whyte E, Kontos AP, Collins MW, O'Connor S.   +5 more
europepmc   +1 more source