Results 171 to 180 of about 39,370 (292)

Social support and adolescent normative behavior in the context of rule of law education: the mediating role of educational expectations among Chinese students. [PDF]

Front Psychol
Guo B.
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Integrated Ultrasonic Platform for Bioelectronic Control through Biological Barriers Based on Metasurface

Advanced Science, EarlyView.
A metasurface‐enabled ultrasonic platform achieves precise multi‐focal control through biological barriers, real‐time physiology‐driven modulation, and simultaneous wireless power and data transmission. By unifying wavefront engineering, closed‐loop feedback, and acoustic communication, this work establishes key enabling technologies toward scalable ...
Chuanxin Zhang, Hanjie Xiao, Xue Jiang, Dean Ta   +3 more
wiley   +1 more source

From Negentropy to Norms - A Gain-Based Theory of Agency: Kerdotism. [PDF]

Integr Psychol Behav Sci
Kypreos M.
europepmc   +1 more source

Fluorescence Tuning of Carbon Dots from Red to Blue via UV‐Induced Photochemical Etching

Advanced Science, EarlyView.
A UV‐driven photochemical process enables continuous color evolution of carbon dots from red to blue using a single irradiation parameter. Progressive photoetching restructures graphitic domains and surface states, allowing full visible‐spectrum emission control.
Nanzhi Zheng, Yuchen Yang, Jingwei Xu, Jincheng Gan, Yinuo An, Xinyu Li, Guohua Chen   +6 more
wiley   +1 more source

Commentary on Buss et al.: State endorsement as a driver of vape-assisted smoking cessation: Interpreting early evidence from Swap to Stop. [PDF]

Addiction
Minian N.
europepmc   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Conceptualizing and Measuring Support for Collective Violence. [PDF]

Aggress Behav
Abou-Ismail R, Phillips JB, Cichocka A, Çakmak H, Çoksan S, Sengupta NK.   +5 more
europepmc   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Commentary: γ-Aminobutyric acid and glutamate dysregulation in the dorsolateral prefrontal cortex of adolescents with first-episode major depressive disorder and the modulatory effects of repetitive transcranial magnetic stimulation. [PDF]

Psychoradiology
Qin B, Cheng S, Chen B, Lu J.
europepmc   +1 more source