Results 41 to 50 of about 84,357 (313)

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer   +3 more
wiley   +1 more source

Epistemic Schmagency? [PDF]

open access: yes, 2018
Constructivist approaches in epistemology and ethics offer a promising account of normativity. But constructivism faces a powerful Schmagency Objection, raised by David Enoch.
Flowerree, A. K.
core  

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

Natural goodness and the political form of human life [PDF]

open access: yesFilozofija i Društvo, 2015
Ethical Naturalism attempts to explain the objective normativity effective in human practices by reference to the relation between a living individual and the life-form it exhibits.
Müller Jan
doaj   +1 more source

Bad News for Ardent Normative Realists?

open access: yesErgo, An Open Access Journal of Philosophy, 2021
According to Ardent Normative Realists, reality favors certain ways of valuing and acting. Matti Eklund has recently argued that Ardent Normative Realists are committed to Referential Normativity, i.e., the thesis that the action-guiding and motivational
François Schroeter, Laura Schroeter
doaj   +2 more sources

Circularity, Naturalism, and Desire-Based Reasons [PDF]

open access: yes, 2017
In this paper, I propose a critique of the naturalist version of the Desire-Based Reasons Model. I first set the scene by spelling out the connection between naturalism and the Model.
Tanyi, Attila
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

A Study of Beall and Restall's Logical Pluralism [PDF]

open access: yesحکمت و فلسفه, 2019
In this paper we will consider the idea of logical pluralism with emphasis on Beall and Restall's (2006) account of pluralism. We begin by specification of logical exclusivism, logical relativism and different accounts of logical pluralism and their ...
Seyed Ali Kalantari, amir karbasizadeh
doaj   +1 more source

Introduction: Towards an Ethics of Mind [PDF]

open access: yes, 2020
This chapter locates our overall approach within the dialectic of contemporary philosophical debates and provides an overall framework for discussion. First, I introduce the problem of mental normativity.
Schmidt, Sebastian
core  

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