The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication [PDF]
Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies.
Cotton, Ben T+6 more
core +2 more sources
Comparative analysis of the extent of protein–protein interactions in icosahedral viral capsids
Abstract Nonenveloped viruses package, carry, and deliver their genomes to the targeted cells using protein shells known as capsids. The viral capsids come in different shapes and sizes, most exhibiting helical or icosahedral symmetries. Here, we analyzed 634 icosahedral capsids at high resolution (<4 Å) from 39 virus families with T‐numbers ranging ...
Noah J. Zimmerman+2 more
wiley +1 more source
Communicable Diseases and the Workplace [PDF]
[Excerpt] Coming to work when we are sick raises some interesting questions: How contagious are we? Should we stay home? What could be done to prevent disease transmission to others, with its effects on absenteeism, performance, and efficiency, as well ...
Brown, Nellie J
core +1 more source
Aquatic food security:insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment [PDF]
Fisheries and aquaculture production, imports, exports and equitability of distribution determine the supply of aquatic food to people. Aquatic food security is achieved when a food supply is sufficient, safe, sustainable, shockproof and sound ...
AB Associates+85 more
core +1 more source
ABSTRACT Introduction Atypical hemolytic uremic syndrome (aHUS) is a disease of complement dysregulation that may lead to kidney failure. Ravulizumab and eculizumab are complement C5 inhibitors approved for the treatment of aHUS. This study assessed the real‐world effectiveness and safety of switching to ravulizumab from eculizumab in kidney transplant
Anja Gaeckler+7 more
wiley +1 more source
Norovirus and Gastroenteritis in Hospitalized Children, Italy
Noroviruses were detected in 48.4% of 192 children (
Claudia Colomba+6 more
doaj +1 more source
Norovirus Infection and Acquired Immunity in 8 Countries: Results From the MAL-ED Study
This longitudinal, multisite study reports a high prevalence of norovirus infection and norovirus-positive diarrhea and describes patterns of age acquisition, disease severity, genogroup-specific immunity, and relationships between norovirus and ...
Saba Rouhani+25 more
semanticscholar +1 more source
Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo. [PDF]
Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo.
Armando Arias+5 more
core +4 more sources
Diagnostic electron microscopy in human infectious diseases – Methods and applications
Abstract Diagnostic electron microscopy (EM) is indispensable in all cases of infectious diseases which deserve or profit from the detection of the entire pathogen (i.e. the infectious unit). The focus of its application has shifted during the last decades from routine diagnostics to diagnostics of special cases, emergencies and the investigation of ...
Michael Laue
wiley +1 more source
Preventing Foodborne Illness: Norovirus
If you have ever had the stomach flu, norovirus was likely the culprit. Norovirus is the most common cause of foodborne illness in the United States and is transmitted through direct person-to-person contact or contaminated objects and food.
Rachael Silverberg+4 more
doaj +5 more sources