Clinical and In Vitro Evidence Favoring Immunoglobulin Treatment of a Chronic Norovirus Infection in a Patient With Common Variable Immunodeficiency. [PDF]
J Infect Dis, 2022 Background Immunocompromised individuals can become chronically infected with norovirus, but effective antiviral therapies are not yet available. Methods Treatments with nitazoxanide, ribavirin, interferon alpha-2a, and nasoduodenally administered ...
van Kampen JJA +10 more
europepmc +2 more sources
Development of a rapid and accurate CRISPR/Cas13-based diagnostic test for GII.4 norovirus infection. [PDF]
Front Microbiol, 2022 Genogroup II genotype 4 (GII.4) norovirus causes acute gastroenteritis in children, and its infection is more severe than that of other genotypes. Early and precise detection and treatment are critical for controlling its spread and reducing the severity
Duan L +10 more
europepmc +2 more sources
The Importance of Secretor-Status in Norovirus Infection Following Allogeneic Hematopoietic Stem Cell Transplantation [PDF]
Viruses, 2022 Background. Human secretor-status is a strong susceptibility factor for norovirus infection in immunocompetent people. The predominant norovirus genotype GII.4 almost exclusively infects secretors and is also associated with more severe symptoms. However,
Lisa Swartling +6 more
doaj +2 more sources
Advances in understanding of the innate immune response to human norovirus infection using organoid models. [PDF]
J Gen Virol, 2022 Norovirus is the leading cause of epidemic and endemic acute gastroenteritis worldwide and the most frequent cause of foodborne illness in the United States.
Mboko WP +4 more
europepmc +2 more sources
Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways. [PDF]
Research (Wash D C), 2022 The composition of commensal bacteria plays a critical role in controlling immune responses in the intestine. Studies have shown that specific bacterial strains may have the capacity to enhance host immune defense against gastrointestinal viral ...
Kim DH +10 more
europepmc +2 more sources
Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids. [PDF]
mSphere, 2021 Although there is an urgent need to develop effective antiviral therapy directed against HuNoV infection, compound screening to identify anti-HuNoV drug candidates has not been reported so far.
Hayashi T +8 more
europepmc +2 more sources
The Role of Host Glycobiology and Gut Microbiota in Rotavirus and Norovirus Infection, an Update. [PDF]
Int J Mol Sci, 2021 Rotavirus (RV) and norovirus (NoV) are the leading causes of acute gastroenteritis (AGE) worldwide. Several studies have demonstrated that histo-blood group antigens (HBGAs) have a role in NoV and RV infections since their presence on the gut epithelial ...
Peña-Gil N +5 more
europepmc +2 more sources
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection [PDF]
mBio, 2020 Several studies have demonstrated that secretor status is associated with susceptibility to human norovirus (HuNoV) infection; however, previous reports found that FUT2 expression is not sufficient to allow infection with HuNoV in a variety of continuous
Kei Haga +12 more
openalex +2 more sources
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis [PDF]
mBio, 2019 Viruses hijack host machinery and regulate cellular homeostasis to actively replicate their genome, propagate, and cause disease. In retaliation, cells possess various defense mechanisms to detect, destroy, and clear infecting viruses, as well as signal ...
Svenja Fritzlar +7 more
openalex +2 more sources
Age-associated features of norovirus infection analysed in mice. [PDF]
Nat Microbiol, 2023 Kennedy EA +5 more
europepmc +2 more sources