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Innate Resistance and Susceptibility to Norovirus Infection
The notion that certain individuals appear more or less susceptible to infections or to specific microbes is not new, but, until recently, it was assumed that clinical outcome of an infection was mainly owing to virulence factors of the microorganism.
Nordgren, Johan+4 more
openaire +6 more sources
Pathology caused by persistent murine norovirus infection [PDF]
Subclinical infection of murine norovirus (MNV) was detected in a mixed breeding group of WT and Stat1 −/− mice with no outward evidence of morbidity or mortality. Investigations revealed the presence of an attenuated MNV variant that did not cause cytopathic effects in RAW264.7 cells or death in Stat1 −/− mice ...
Amita Shortland+7 more
openalex +5 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E.+4 more
core +2 more sources
Norovirus (NoV) es la causa más común de gastroenteritis aguda esporádica o epidémica en niños en edad escolar, adolescentes y adultos. En lactantes y niños pequeños, es la segunda más frecuente después de rotavirus. La diversidad entre los NoV es muy grande. Se distinguen 5 genogrupos (G) y 29 genotipos; las cepas humanas
Eduardo Salazar Lindo+1 more
openaire +1 more source
Background Norovirus is the leading cause of sporadic viral gastroenteritis cases and outbreaks. Gut microbiota plays a key role in maintaining immune homeostasis.
Jie Li+8 more
doaj +1 more source
Norovirus outbreaks severely disrupt healthcare systems. We evaluated whether Websök, an internet-based surveillance system using search engine data, improved norovirus surveillance and response in Sweden.
Michael Edelstein+3 more
doaj +1 more source
Immunology of Norovirus Infection
Noroviruses are the leading cause of epidemic non-bacterial gastroenteritis worldwide. Despite their discovery over three decades ago, little is known about the host immune response to norovirus infection. The purpose of this chapter is to review the field of norovirus immunology and discuss the contributions of outbreak investigations, human and ...
Menira Souza+5 more
openaire +2 more sources
Norovirus and Sapovirus Infections in Thailand
Stool specimens collected between November 2002 and April 2003 from hospitalized infants with acute gastroenteritis from four distinct geographical regions in Thailand were examined for norovirus (NoV) and sapovirus (SaV) by reverse transcription-PCR and sequence analysis.
Ratigorn, Guntapong+6 more
openaire +2 more sources
Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William+2 more
core +1 more source
Re-assessing the total burden of norovirus circulating in the United Kingdom population [PDF]
The second Infectious Intestinal Diseases study (IID2) estimated the incidence of norovirus in the UK at 47/1000 population (three million cases annually). Clinically significant norovirus was defined using a cycle threshold (ct) value of
Harris, John P+2 more
core +1 more source