Results 71 to 80 of about 3,213,792 (286)

Illuminating Human Norovirus: A Perspective on Disinfection of Water and Surfaces Using UVC, Norovirus Model Organisms, and Radiation Safety Considerations

Pathogens, 2022
Human noroviruses (HuNoVs) are a major cause of gastroenteritis and are associated with high morbidity because of their ability to survive in the environment and small inoculum size required for infection.
Richard M. Mariita, James H. Davis, Rajul V. Randive   +2 more
doaj   +1 more source

Research advances in disinfection and inactivation methods for norovirus

Zhongguo gonggong weisheng
Norovirus is a leading cause of acute gastroenteritis in humans worldwide. Norovirus infection is characterized by low infectious dose, high viral shedding, strong environmental resistance and multiple modes of transmission, making it difficult to ...
Surui JIANG, Huiying LI, Zhaojun DUAN
doaj   +1 more source

Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011.

PLoS ONE, 2015
BackgroundSuccessful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries
Sarah-Blythe Ballard, Erik J Reaves, C Giannina Luna, Maria E Silva, Claudio Rocha, Kristen Heitzinger, Mayuko Saito, Sonia Apaza, Susan Espetia, David L Blazes, Drake H Tilley, Rene C Guzmán Aguilar, Robert H Gilman, Daniel G Bausch   +13 more
doaj   +1 more source

Recent advances in understanding noroviruses [version 1; referees: 2 approved]

F1000Research, 2017
Noroviruses are the leading cause of acute gastroenteritis around the world. An individual living in the United States is estimated to develop norovirus infection five times in his or her lifetime. Despite this, there is currently no antiviral or vaccine
Eric Bartnicki, Juliana Bragazzi Cunha, Abimbola O. Kolawole, Christiane E. Wobus   +3 more
doaj   +1 more source

Human norovirus infection in Latin America [PDF]

Journal of Clinical Virology, 2016
Noroviruses are important enteric pathogens involved in non-bacterial gastroenteritis outbreaks worldwide. Noroviruses mainly occur from person to person via the fecal-oral route but also through contaminated food or water; indirect contamination is also possible due to the resistance of the virus in the environment. Latin American countries as a whole
Luiz Claudio Nogueira Mendes, Louisa Ludwig, Edmilson Ferreira de Oliveira-Filho, Filemon Bucardo, Pierrette Melin, Etienne Thiry, Pascale Huynen, Tatiane da Silva Poló, Tatiane da Silva Poló, Axel Mauroy, Juliana Regina Peiró   +10 more
openaire   +3 more sources

Lack of Effect of Murine Norovirus Infection on a Mouse Model of Bacteria-Induced Colon Cancer [PDF]

, 2011
Murine norovirus (MNV) is endemic in mouse research facilities in the United States and Europe, with a prevalence as high as 58% to 64%. Because of MNV's orofecal route of infection, clinically silent persistent infections in some mouse strains, and ...
Brabb, Thea, Drivdahl, Rolf, Lencioni, Karen C., Maggio-Price, Lillian, Seamons, Audrey, Treuting, Piper M.   +5 more
core   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Natural Norovirus Infections in Rhesus Macaques [PDF]

Emerging Infectious Diseases, 2016
Using a recently developed real-time reverse transcription PCR, I retested 500 fecal samples from rhesus macaques collected in 2008. Previous conventional reverse transcription PCR testing identified 1 isolate of GII norovirus; retesting found GI, GII, and possible GIV noroviruses in the samples, indicating the natural circulation of noroviruses in ...
openaire   +3 more sources

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

PLoS Pathogens, 2019
Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis ...
Hanne Dubois, F. Sorgeloos, S. T. Sarvestani, L. Martens, Y. Saeys, J. Mackenzie, M. Lamkanfi, G. van Loo, I. Goodfellow, A. Wullaert   +9 more
semanticscholar   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source