Results 71 to 80 of about 5,504,994 (361)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Large shift in symbiont assemblage in the invasive red turpentine beetle.

open access: yesPLoS ONE, 2013
Changes in symbiont assemblages can affect the success and impact of invasive species, and may provide knowledge regarding the invasion histories of their vectors. Bark beetle symbioses are ideal systems to study changes in symbiont assemblages resulting
Stephen J Taerum   +6 more
doaj   +1 more source

Longitudinal patterns of health-related quality of life and dialysis modality: a national cohort study

open access: yesBMC Nephrology, 2019
Background Health-related quality of life (HrQoL) varies among dialysis patients. However, little is known about the association of dialysis modality with HrQoL over time.
Nwamaka D. Eneanya   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Certificate of affiliation given to Meat Cutters by Amalgamated Meat Cutters and Butcher Workmen of North America

open access: yes, 1939
Certificate of affiliation given to Meat Cutters by Amalgamated Meat Cutters and Butcher Workmen of North America, local union #340, Wichita, Kansas. Legible names on the document include A.T.
Amalgamated Meat Cutters and Butcher Workmen of North America
core  

Distribution of Sphingidae of Western North America, revised [PDF]

open access: yes, 1995
Includes bibliographical references (page 4).This is the second number of a series of atlases detailing the distributional occurrence of the moths of North America.
C.P. Gillette Museum of Arthropod Diversity, publisher   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Certificate of affiliation given to Retail Meat Cutters by Amalgamated Meat Cutters and Butcher Workmen of North America

open access: yes, 1939
Certificate of affiliation given to Retail Meat Cutters by Amalgamated Meat Cutters and Butcher Workmen of North America, local union #536, Springfield, Missouri. Legible names on the document include Alvie Hall, Frank Ream, Frank Artlett, John McDaniel,
Amalgamated Meat Cutters and Butcher Workmen of North America
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy