Results 31 to 40 of about 1,651,484 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Energies, 2023 The “One Belt and One Road” strategy provides a new opportunity for deepening oil and gas energy cooperation between China and Central-North Asian countries.
Mingchen Duan, Yi Duan
doaj +1 more source
Hydrological variations in central China over the past millennium and their links to the Tropic Pacific and North Atlantic Oceans [PDF]
, 2020 Variations of precipitation, aka the Meiyu rain, in East Asian summer monsoon (EASM) domain during the last millennium could help enlighten the hydrological response to future global warming.
Chen, Jianshun +7 more
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Dizhen xuebao基于唐海—商都宽频带地震台阵2006—2009年连续三年的波形记录，利用环境噪声相位自相关函数对台阵下方的莫霍面反射P波进行分析。通过对同一个台站多个时间段的自相关结果进行分组、采用两步叠加处理增加信号强度：① 在组内进行线性叠加，对组间的叠加结果进行相位加权叠加；② 基于华北地区的背景速度结构信息，在地壳平均速度5%不确定性的时窗内，根据自相关函数包络线的二阶导数最大值确定P波的莫霍面反射时间，经时间−深度转化，获得台阵下方的莫霍面深度。结果显示，莫霍面从东南向西北总体由浅变深，中间有小幅度的起伏 ...
Hongpu Wei, Aihua Zhao
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Infection and Drug Resistance, 2023 Yanhui Wang,1,* Jian Ren,2,* Zhiqing Yao,1 Wei Wang,3 Siyang Wang,2 Junfang Duan,3 Zhen Li,4 Huizi Zhang,1 Ruiqin Zhang,2 Xiaoru Wang3 1College of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of ...
Wang Y +9 more
doaj
Contrasted tectonic styles for the Paleoproterozoic evolution of the North China Craton. Evidence for a ~2.1 Ga thermal and tectonic event in the Fuping Massif [PDF]
, 2008 International audienceStructural analysis along with 40Ar–39Ar and U–Pb datings in the Fuping massif provide new insight into the evolution of the eastern part of the Trans-North China Belt (North China Craton), from 2.7 Ga to 1.8 Ga.
Bruguier, Olivier +4 more
core +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Dizhen xuebao为了解首都圈地区电性莫霍面（eMoho）的分布情况，使用该地区电磁台网部分台站的长周期大地电磁数据，反演得到了首都圈地区的深部电性结构，该结果与前人使用地震、电磁、重力等资料得到的研究区地下结构具有较好的一致性，同时表明首都圈地区的地震学莫霍面附近也存在着电阻率变化特征。在此基础上，对反演所得的电阻率曲线求取一阶导数，以此来刻画测点下方电性莫霍面的深度位置，继而建立三类地层模型验证了该方法的可行性，并对实测资料反演结果求取一阶导数，结果凸显了电性莫霍面的分布，所得电性莫霍面与地震 ...
Kexin Zhu, Xingong Tang, Junhu Yu
doaj +1 more source