Results 111 to 120 of about 1,021,843 (291)

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Archeological Investigations at the Hudnall-Pirtle Site (41RK4) An Early Caddo Mound Center in Northeast Texas [PDF]

, 2006
The Hudnall-Pirtle site (41RK4) is situated on a large T-1 alluvial terrace of the Sabine River in northern Rusk County in Texas. This area of the state, commonly called Northeast Texas, is part of the Southern Gulf Coastal Plain, a relatively level ...
Bruseth, James E., Fritz, Gayle J., Perttula, Timothy K., Yates, Bonnie C.   +3 more
core   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Selectively Inhibition of MAPK pathway showed positive effects on Porcine embryo-derived stem cells pluripotency

Scientific Reports
Expanded pluripotent stem cells (EPSCs), derived from pre-implantation embryos in specific culture conditions, can contribute to both embryonic and extraembryonic lineages.
Zhuoran Yu, Mengjiao Zhang, Yanjiao Lv, Minli Liu, Yue Yu, Sirong Li, Sihan Zhou, Chaoqian Jiang, Zicheng Qi, Hongxing Wang, Jun Song, Xiaogang Weng, Xiuqin Yang, Tingsheng Yan, Zhonghua Liu   +14 more
doaj   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Memória coletiva de culturas do Nordeste

Ciências Sociais Unisinos, 2011
Considering Juazeiro do Norte, in the state of Ceará, as a field of empirical approach, this study is based on the notion that in order to know an area in a social, cultural, and geographical sense, it is necessary to know the experiences of its people ...
Domingos Sávio de Almeida Cordeiro
doaj  

Winter Canola Variety Trial [PDF]

, 2012
In 2012, the University of Vermont Extension Northwest Crops and Soils Program initiated a winter canola variety trial in Alburgh, VT as part of the 2011-2012 National Winter Canola Variety Trial.
Blair, Katie, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +5 more
core   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Winter Barley Variety Trial [PDF]

, 2014
With the revival of the small grains industry in the Northeast and the strength of the localvore movement, craft breweries and distilleries have expressed an interest in sourcing local barley for malting.
Blair, Katie, Cummings, Erica, Darby, Heather, Monahan, Susan, Post, Julian, Ziegler, Sara   +5 more
core   +1 more source