Results 161 to 170 of about 1,021,843 (291)

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Population genomics reveals deep diversification in Malayan pangolins. [PDF]

Mol Biol Evol
Li B, Li H, Shi M, Wang Q, Li H, Guo C, Hu J, Liu B, Tian Y, Liu S, Finch K, Wang S, Yang S, Cui L, Li J, Zhao X, Deng Z, Ma Y, Kim HJ, Wasser SK, Wang K, Lu H, Chen J, Guo H, Yao Y, Xie H, Wang Y, Fan J, Lin Y, Hou Y, Fu Y, Jiang C, Lu J, Li S, Qiu Z, Zhang W, Bai S, Han L, Wang Z, Wang C, Li J, Jiang Y, Liu S, Wang J, Yu L, Li Q, Li L, Hua Y, Lan T, Xu Y.   +49 more
europepmc   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Wen‐Xue Li, Qingguo Du   +7 more
wiley   +1 more source

Developing indicators of risk to environmental variability based on species dependency in U.S. fishing communities in the Northeast and Southeast Regions. [PDF]

PLoS One
Seara T, McPherson M, Clay PM, Jepson M, Colburn LL, Weng C, Silva A.   +6 more
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Implications of the Clean Air Act Amendments for the Northeast

Maine Policy Review, 1993
Joseph Belanger
doaj  

Space-Time scan of tuberculosis indicators in Northeast Brazil: an ecological and time-series study over 20 years (2001-2020). [PDF]

BMC Public Health
Souza MDR, Dos Santos Sales VB, de Jesus GFH, Andrade LA, de Oliveira Costa AC, de Souza CDF, de Sousa ÁFL, Sanches PPDSP, Dos Santos AD, Camargo ELS, Lima SVMA, Araújo KCGM, Mendes IAC, Bezerra-Santos M.   +13 more
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Harmonized geospatial data to evaluate the Electric Distribution Networks in the US Northeast. [PDF]

Sci Data
Salbanya B, Nin J, Gras Alomà R.
europepmc   +1 more source