Results 31 to 40 of about 1,235,631 (341)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Attribution of the record-breaking heat event over Northeast Asia in summer 2018: the role of circulation

open access: yesEnvironmental Research Letters, 2020
In summer 2018, an extraordinary heat wave with record-breaking high temperatures hit Northeast Asia. However, the contribution of atmospheric circulation to this heat wave remains unknown.
Liwen Ren, Tianjun Zhou, Wenxia Zhang
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Northeast Glaciers [PDF]

open access: yes, 2003
This reference guide provides a brief review of glaciers in the Northeastern U.S. It then focuses on the glacial affects in four areas, an inland basin near the Finger Lakes area of New York, the Appalachian/Piedmont through New York and Pennsylvania ...

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Synchronous 500-year oscillations of monsoon climate and human activity in Northeast Asia

open access: yesNature Communications, 2019
Prehistoric human activities were likely influenced by cyclic monsoon climate changes in East Asia. Here we report a decadal-resolution Holocene pollen record from an annually-laminated Maar Lake in Northeast China, a proxy of monsoon climate, together ...
Deke Xu   +7 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Using feed-forward strategies in higher education. The terrifying novel assignment: using feed-forward to improve students' ability and confidence on assignments that test new skills [PDF]

open access: yes, 2016
Within higher education it is strongly agreed that feedback is the most important way of raising student achievement and encouraging student learning (Gibbs and Simpson, 2005).
Hine, Ben, Northeast, Tony
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Factors Affecting the Promotion of Conservation Tillage in Black Soil—The Case of Northeast China

open access: yesSustainability, 2021
Taking the conservation tillage influences of black soil in Northeast China as the research object, the paper is written according to the advice of relevant experts and technicians in Northeast China, the study also calculates the weight of each ...
Yan Qu, Chulin Pan, Hongpeng Guo
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

State of the Sector [PDF]

open access: yes, 2012
In 2005, the Jessie Ball duPont Fund and the then-young Nonprofit Center of Northeast Florida asked a fundamental question: how many nonprofits operate in our community and what do they do? When the answer was not readily available, the two organizations

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