Results 41 to 50 of about 879,535 (309)

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

The beginning of time? Evidence for catastrophic drought in Baringo in the early nineteenth century [PDF]

, 2016
New developments in the collection of palaeo-data over the past two decades have transformed our understanding of climate and environmental history in eastern Africa.
Anacleti A. Odhiambo, Anderson David M., Anderson David M., Avanchers P. Leon des, Baxter P. T. W., Bollig Michael, Bollig Michael, Bollig Michael, David M. Anderson, Davies Matthew I. J., Davies Matthew I. J., Dietz Ton, Dundas K. R., Fosbrooke H. A., Herring Ralph, Hollis A. C., Hughes Lotte, Huntingford G. W. B., Jacobs Alan H., Krapf J. L., Krapf L. J., Lamphear John, Lamphear John, Lamphear John, Lamphear John, Lamphear John, Little Peter D., McCann James C., Nicholson Sharon E., Nicholson Sharon E., Peristiany J. G., Prins A. J. H., Rubensen Sven,, Schlee Gunther, Shetler Jan Bender, Sobania Neal P., Spencer Paul, Spencer Paul, Spencer Paul, Thomson Joseph, Turton David, Verschuren Dirk, Verschuren Dirk, Verschuren Dirk, Waller Richard D., Waller Richard D., Webster J. B., Webster J. B.,   +47 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Ineffective programme management on the delivery of health infrastructure projects: A case of the Northern Cape

Acta Structilia, 2016
Programme management remains a challenging management practice in the Northern Cape Department of Health (NCDoH), particularly when a health facility project has to integrate the components of construction management and operations management in order to
Lesetja Mabona, Winston Shakantu
doaj   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Split westerlies over Europe in the early Little Ice Age

Nature Communications, 2022
A new stalagmite record from northern Italy and other published data from Europe and northern Africa reveals a split in the climatological westerlies during the early LIA, possibly attributed to sea ice melting.
Hsun-Ming Hu, Chuan-Chou Shen, John C. H. Chiang, Valerie Trouet, Véronique Michel, Hsien-Chen Tsai, Patricia Valensi, Christoph Spötl, Elisabetta Starnini, Marta Zunino, Wei-Yi Chien, Wen-Hui Sung, Yu-Tang Chien, Ping Chang, Robert Korty   +14 more
doaj   +1 more source

The Saharan heat low and moisture transport pathways in the central Sahara-multiaircraft observations and Africa-LAM evaluation [PDF]

, 2015
We present a characterization of the Saharan heat low (SHL) based on dropsonde observations made on 22 June 2011 by two simultaneously flying aircraft during the Fennec project.
Allen, Allen, Ansmann, Biasutti, Bou Karam, Chauvin, Cuesta, Cuesta, Cullen, Dai, Dee, Engelstaedter, Evan, Evan, Flamant, Gamo, Garcia-Carreras, Garcia-Carreras, Grams, Haywood, Hobby, Israelevich, Johnson, Knippertz, Lafore, Lavaysse, Lavaysse, Lavaysse, Lavaysse, Lebel, Marsham, Marsham, May, McConnell, Mera, Messager, Parker, Peyrille, Prospero, Roehrig, Schepanski, Schmetz, Solomos, Sultan, Thorncroft, Todd, Walters, Washington, Washington   +48 more
core   +3 more sources

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source

The influence of European pollution on ozone in the Near East and northern Africa [PDF]

Atmospheric Chemistry and Physics, 2008
We present a modeling study of the long-range transport of pollution from Europe, showing that European emissions regularly elevate surface ozone by as much as 20 ppbv in summer in northern Africa and the Near East.
B. N. Duncan, J. J. West, Y. Yoshida, A. M. Fiore, J. R. Ziemke   +4 more
doaj