Results 51 to 60 of about 6,785 (254)
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Advanced Science, EarlyView.Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo +10 more
wiley +1 more source
Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression
Advanced Science, EarlyView.The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren +20 more
wiley +1 more source
AgronomyThis study assessed the impact of planting techniques and short-term organic additions on soil quality, enzyme activity, and bacterial community composition.
Ziqi Liu +6 more
doaj +1 more source
Properties of Recurrent Nova T Pyxidis Based on 2011 Outburst
Acta Polytechnica CTU Proceedings, 2015 We reexamine the properties of the recurrent nova T Pyxidis based on our own spectroscopic data accompanying with the photometric ones by VSOLJ (Variable Star Observers League in Japan) during 2011 outburst. One of the purpose of this paper is whether a
K. Tanabe
doaj +1 more source
Advanced Science, EarlyView.This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang +10 more
wiley +1 more source
LandAssessing the suitability of human settlements is of great significance for promoting pastoral development, improving herders’ livelihoods, and advancing the construction of beautiful villages in agro-pastoral regions.
Sen Mu +3 more
doaj +1 more source
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Towards an understanding of maltreatment in football
Frontiers in Sports and Active LivingIntroductionThis study explored the understanding of maltreatment from the perspective of various personnel working in roles related to safeguarding and welfare in English professional and semi-professional football.MethodThrough a social constructivist ...
James A. Newman, James L. Rumbold
doaj +1 more source