Results 51 to 60 of about 187,427 (307)
Frontiers in Marine Science, 2022 During the last decades, many wild Atlantic salmon populations have declined dramatically. One hypothesis for an observed reduction in salmon marine growth and survival is reduced abundance of prey.
Kjell Rong Utne +5 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Polychlorinated biphenyls in air and water of the North Atlantic and Arctic Ocean. [PDF]
, 2008 Air and seawater samples were collected on board the R/V Polarstern during a scientific expedition from Germany to the Arctic Ocean during June–August 2004.
Dachs, Jordi +7 more
core +3 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Ecology and Evolution, 2021 Habitat changes represent one of the five most pervasive threats to biodiversity. However, anthropogenic activities also have the capacity to create novel niche spaces to which species respond differently.
María Quintela +9 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Knowledge status and gaps for the North Sea – focusing on discharges. [PDF]
, 2008 The Norwegian government will develop a management plan for the Norwegian sector of the North Sea. Mapping of the data requirement related to the interaction between land, coast and ocean and identification of specially vulnerable and valuable areas are ...
Folkestad, Are +11 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fauna Norvegica, 2010 A new species of Thyasiridae, Thyasira ockelmanni n.sp. is described from the abyssal depths of the Norwegian Sea. The generic assignment is tentative and possible alternatives are discussed.
Rozemarijn Keuning, Christoffer Schander
doaj +1 more source