Results 91 to 100 of about 215,796 (301)

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, EarlyView.
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R. Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source

Evidence for functional convergence between LZTS2 and DYRK1A during craniofacial development

Developmental Dynamics, EarlyView.
Abstract Background Precise control of DYRK1A dosage is essential for embryonic development, including craniofacial morphogenesis. While LZTS2 is among the most consistently identified DYRK1A‐interacting proteins, its roles in embryonic development remain incompletely understood, and its potential contribution to craniofacial development has not been ...
Nicole Cheng, Santiago Lima, Larisa Litovchick, Amanda J. G. Dickinson   +3 more
wiley   +1 more source

Use of volatile fingerprints for rapid screening of antifungal agents for efficacy against dermatophyte Trichophyton species [PDF]

, 2010
The potential of using an electronic nose (E-nose) as a rapid technique for screening the responses of dermatophytes to antifungal agents was studied.
Barr, Hugh, Magan, Naresh, Sahgal, Natasha, Naraghi, Kamran, Adriaans, Beverley, Natasha Sahgal, Beverley Adriaans, Kamran Naraghi, Hugh Barr, Naresh Magan   +9 more
core   +1 more source

Proportion, Five‐Year Survival Rate of Laryngeal Cancer and Its Associated Factors Among Head and Neck Cancer Patients in Tanzania

Eye &ENT Research, EarlyView.
ABSTRACT Background Laryngeal cancer carries a significant global burden, with substantial morbidity and mortality, and is increasing globally, with 95%–98% being squamous cell carcinoma. Males are more affected than females, with peak cases occurring between 60 and 80 years of age.
Amenye Adili, Furaha Serventi, Baraka M. Musimu, Mica Magembe, Orest Tarimo, Geofrey Ikelesho, Salum Kalonge, Leonard Kiboko, Queen Godfrey Tarimo, Desderius C. Chussi   +9 more
wiley   +1 more source

Natural history of a nasolabial hemangioma [PDF]

Einstein (São Paulo), 2006
Hemangiomas of infancy are unique, benign tumors of endothelialcells characterized by an initial phase of rapid proliferation, followedby slow involution, often leading to complete regression.
Ronaldo Golcman, Benjamin Golcman, Murilo Francisco Pires Fraga   +2 more
doaj  

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Photodynamic therapy of basal cell carcinoma of the face H-zone

Biomedical Photonics
This article reviews clinical experience in treating skin neoplasms using photodynamic therapy with combined ultrasound and fluorescence diag- nostics for neoplasms in the nose, lateral face, and adjacent areas.
E. V. Nadkernichnaya, M. V. Ermoschenkova, V. E. Semin, S. A. Parts, V. N. Galkin, I. V. Reshetov   +5 more
doaj   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Reconstrução nasal complexa: opções cirúrgicas numa série de casos

Revista Brasileira de Cirurgia Plástica
INTRODUÇÃO: As reconstruções nasais complexas têm alcançado alto nível de sofisticação, enfatizando-se a necessidade de substituir os tecidos nasais por outros similares.
Rodrigo Campos Soares Quintas, Gerson Parisio Araújo, José Helder Gomes de Matos Medeiros Junior, Lóren Faae Feitosa Moreira Quintas, Marco Antônio Pinto Kitamura, Ernando Luiz Ferraz Cavalcanti, Camila Maria Nascimento Firme, Romero Antônio de Oliveira Glasner   +7 more
doaj   +1 more source