Results 51 to 60 of about 39,080 (310)

Particulate matter – a cancerous threat to our health?

Journal of Education, Health and Sport, 2023
Introduction: Particulate matter (PM) as a part of outdoor air pollutants are classified as human carcinogens. They are formed majorly as a result of combustion process by industry, power plants and engines.
Adam Jasiura, Wiktoria Lipczyńska, Konrad Warchoł, Mateusz Gorzel, Agata Justyńska, Hanna Krafzik, Przemysław Stępień, Hubert Kasprzak   +7 more
doaj   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Rare Cases in ENT

Bengal Journal of Otolaryngology and Head Neck Surgery, 2020
In our day to day ENT practice we commonly come across diseases involving the larynx, the oral cavity and the paranasal sinuses. These range from inflammatory disorders to benign and malignant neoplasms.
Kalyan Pal, Dipanjan Chakraborty, Sohag Kundu, Subrata Mukhopadhyay   +3 more
doaj   +1 more source

Sinonasal inverted papilloma; recurrence, malignant transformation and risk factors [PDF]

, 2019
Sinonasal inverted papilloma is a rare benign epithelial tumor. Its three main clinical characteristics are the tendency of recurrence, the destructive ability of nearby structures and malignant transformation.
Ghindea, Teodora, Hainarosie, Razvan, Ionita, Irina, Mazilu, Laura, Meius, Alexandru, Nitipir, Cornelia, Pietrosanu, Catalina, Pituru, Silviu, Rusescu, Andreea, Timofte, Daniel   +9 more
core   +1 more source

Spindle Cell Neoplasm of Bridge of Nose

Bengal Journal of Otolaryngology and Head Neck Surgery
Introduction: Spindle cells are a feature of many benign and malignant mesenchymal tumors. Differentiating benign versus malignant tumors is based on the presence and type of extracellular matrix, the nuclear and cytoplasmic features of the spindle cells, and the presence of mitoses and necrosis. In bone tumors, the imaging is often predictive. Fibrous
Tamajit Sau, Bibhas Mondal, Saumitra Kumar   +2 more
openaire   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Autograft reconstruction of nasal dorsum in cutaneous neoplasia treatment

RGO: Revista Gaúcha de Odontologia, 2022
Basal cell carcinoma is the most common type among skin cancers. It occurs in basal cells and is primarily caused by sun exposure. It mainly affects elderly people, mainly man, in exposed areas of the body and is diagnosed through biopsy.
Camilla Siqueira de AGUIAR, Milena Mello Varela Ayres de Melo PINHEIRO, Rodrigo Henrique Mello Varela Ayres de MELO, Victor Leonardo Mello Varela Ayres de MELO, Lohana Maylane Aquino Correia de LIMA, Arnaldo de França CALDAS JÚNIOR, Ricardo Eugenio Varela Ayres de MELO   +6 more
doaj   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

TUMORS OF THE NOSE AND PARANASAL SINUSES IN CHILDREN, CLINICAL OBSERVATIONS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Resume. Neoplasms of the nasal cavity and perinasal sinuses at the beginning of their development are asymptomatic or non-specific symptoms may appear that mask them as inflammatory diseases (acute and chronic rhinosinusitis).
Rakova S. N., Halavach K. N., Logis O. V., Borodavko P. N., Bobrishev A. I.   +4 more
doaj   +1 more source

Olfactory Neuroblastoma: Diagnostic Difficulty [PDF]

, 2011
Olfactory neuroblastoma is an uncommon malignant tumor of sinonasal tract arising from the olfactory neuro epithelium. The olfactory neuroblastomas presenting with divergent histomorphologies like, epithelial appearance of cells, lacking a neuro ...
Biswas, Siddhartha, MN, Vidya, S, Vijay Shankar, Shivakumar, Swarna   +3 more
core   +1 more source