Results 41 to 50 of about 3,415,496 (317)

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Characterization of Tigecycline-Heteroresistant Klebsiella pneumoniae Clinical Isolates From a Chinese Tertiary Care Teaching Hospital

Frontiers in Microbiology, 2021
Tigecycline has been used as one of the therapeutic choices for the treatment of infections caused by multidrug-resistant Klebsiella pneumoniae. However, the emergence of tigecycline heteroresistance has led to great challenges in treating these ...
Qiaoyu Zhang, Liping Lin, Yuhong Pan, Jiansen Chen   +3 more
doaj   +1 more source

Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network [PDF]

, 2018
BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units ...
Agodi A, Arrigoni C, Auxilia F, Barchitta M, Brusaferro S, D'Errico MM, Fabiani L, Laurenti P, Mattaliano AR, Montagna MT, Mura I, Orsi GB, Pasquarella C, Squeri R, Tardivo S, Torregrossa MV   +15 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae

Annals of Clinical Microbiology and Antimicrobials
Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K ...
Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen   +5 more
doaj   +1 more source

Modeling Nosocomial Disease Outbreaks using a Combined Differential Equations and Agent Based-Modeling Approach [PDF]

, 2016
A nosocomial infection is an infection that a patient develops while in a hospital or healthcare related setting, also known as a hospital acquired infection (HAI).This project has two foci: firstly to model a HAI within an individual, then secondly to ...
FitzGerald, Cody Eion
core   +1 more source

Metal–Organic Framework‐Based Antimicrobial Touch Surfaces to Prevent Cross‐Contamination

Advanced Materials, EarlyView.
A MOF‐based antimicrobial door handle cover is developed. It completely inhibits the cross‐contamination of Gram‐positive bacterial species (Staphylococcus aureus, and Enterococcus faecalis), Gram‐negative bacterial species (Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii), and fungi (Candida albicans). Abstract Infection diseases
Javier Fonseca, Mary Cano‐Sarabia, Pilar Cortés, Jordi Saldo, David Montpeyó, Julia Lorenzo, Montserrat Llagostera, Inhar Imaz, Daniel Maspoch   +8 more
wiley   +1 more source

Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations [PDF]

, 2017
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide.
A Higgins, A Jamal, A Lipitz-Snyderman, A Pinto, AF Vicca, AJ Howie, AM Yinnon, AR Marra, AS Mathai, B Allegranzi, BA Mark, BN Reames, BS Koll, BW Thomas, C Brandt, C Fuller, CS Cocanour, D Fisher, D Pittet, D Pittet, D Quiros, DD Wirtschafter, DG Bundy, DJ Birnbach, DM Henderson, E Creamer, Effective Practice and Organisation of Care (EPOC), EG Shepherd, EL Geubbels, EL Larson, F L’Heriteau, F Schwab, G Pontivivo, GB Allen, GH Guyatt, HW Kilbride, I Zuschneid, International Health Regulations, J Alonso-Echanove, J Bion, J Blatnik, J Mayer, J Robert, JA Al-Tawfiq, JA Marsteller, JB Cunningham, JB Cunningham, JB Cunningham, JH Barsuk, JH Jang, JJ Anderson, JW Lederer Jr, KB Kirkland, KB Stevenson, L Bouadma, L Charrier, L Gerolemou, L Johnson, L Rubinson, LA Mermel, LJ Damschroder, LL McKinley, M Thomas, M Virtanen, M Whitby, MA Borg, MA Borg, MD Koff, ML Grayson, ML McLaws, ML McLaws, ML Render, ML Schweizer, MR Miller, MR Miller, N Petrosillo, P Eggimann, P Gastmeier, P Gastmeier, P Gastmeier, P Gastmeier, PW Nicol, R Jain, R Peredo, RJ Sherertz, RM Sladek, RW Haley, S Barwolff, S Hansen, S Hugonnet, S Hugonnet, S Hugonnet, S Newitt, S Nijssen, SA Creedon, SC Joshi, SI Doron, SK Fridkin, SM Brown, SR Lieber, TR Talbot, V Rodriguez, VA DePalo, VD Rosenthal, VD Rosenthal, VD Rosenthal, VD Rosenthal, W Moongtui, W Turnberg, W Zingg, W Zingg, W Zingg, WN Viana, YL Kwok   +113 more
core   +9 more sources

The Difference of Nosocomial Urinary Tract Infection Risk Based on Chateterization Urine, Age, and Diabetes Mellitus [PDF]

, 2015
Nosocomial urinary tract infection is common occurs in patients with indwelling urinary chateter. Factors that caused nosocomial urinary tract infection are host, agent, and chateterization urine.
Sari, E. W. (Edel), Satyabakti, P. (Prijono)   +1 more
core   +2 more sources

Antimicrobial Multi‐Assay Evaluation of (Al‐Doped ZnO)‐Ag and TiO2‐Ag Nanocoatings: Impact of Direct and Indirect Mechanisms

Advanced Materials Interfaces, EarlyView.
This work explores the antimicrobial action of AZO‐Ag and TiO2‐Ag nanocoatings on plastic, demonstrating good efficacy against highly‐critical antibiotic‐resistant bacteria, yeast, and virus. A multi‐assay approach is here exploited to inspect the contribution of direct and indirect antimicrobial mechanisms, and potential human toxicity is also ...
Damiano Squitieri, Roberta Vitali, Cecilia Bartoleschi, Giulia Lombardini, Margherita Cacaci, Lorenzo Degli Esposti, Camilla Fusacchia, Skerxho Osmani, Luca Gavioli, Francesca Bugli, Daniele Valerini   +10 more
wiley   +1 more source