Results 11 to 20 of about 16,504 (149)
Phanerozoic Large Igneous Province, Petroleum System, and Source Rock Links
Geophysical Monograph Series, Page 191-228., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Steven C. Bergman +2 more
wiley +1 more source
Advanced Science, EarlyView.The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang +9 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Dicynodonts (Anomodontia: Dicynodontia) were one of the main groups of terrestrial tetrapods in Permian and Triassic faunas. In Brazil, the genus Dinodontosaurus is one of the most common tetrapod taxon in the Triassic Santa Maria Supersequence. This genus has a complex taxonomic history and is represented in the Triassic of both Argentina and
Julia Lara Rodrigues de Souza +5 more
wiley +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Proyecto: Formación de jóvenes investigadores en semilleros de investigación
Palobra, 2001 El departamento de Investigaciones y Desarrollo de la Facultad de Ciencias Sociales y Educación reconociendo la necesidad de construir espacios académicos más creativos y comprometidos con la generación del saber y que la investigación es parte esencial
Notas Notas
doaj
Revista de História, 1964 Os sistemas mais antigos da índia não são os seis sistemas filosóficos, Mimânsâ, Vedânta, Sâmkhya, Ioga, Vaiçeshika e Nyâya, mas as duas escolas do pensamento e da religião, o Janismo e o Budismo que negam a autoridade dos Vedas, a validade dos ritos e ...
Jorge Bertolaso Stella
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu +4 more
wiley +1 more source