Results 141 to 150 of about 60,049 (256)

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas. [PDF]

Clin Exp Med
Luo Y, Wang R, Xu Y, He M, Zhou Q, Wang G, Ye G, Xu C, Wang W, Cai S, Peng F, Zhu X.   +11 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Colorectal Cancer Organoid Model Reveals the Mechanisms of Irinotecan Resistance at Single-Cell Resolution. [PDF]

Cancer Med
Pan Y, Chen L, Hu Y, Chang J, Xu X, Xu S, Li Y, Du J, Wang J, Xu W.   +9 more
europepmc   +1 more source

Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

BMEMat, EarlyView.
This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.
Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang   +9 more
wiley   +1 more source

An integrated physics-guided machine learning approach for predicting asphalt concrete fracture parameters. [PDF]

Sci Rep
Elahi M, Khan R, Mabood T, Khan MS, Ahmed A, Ahmad M, Tóth Z.   +6 more
europepmc   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

Incidence and geographic mapping of meniscal tears in acute ACL injuries with meticulous posterior arthroscopic evaluation: longitudinal tears at the posterior menisco-capsular junction are the most common tear pattern in acute ACL injuries. [PDF]

Knee Surg Relat Res
Kim DH, Lee DK.
europepmc   +1 more source

Notch sensitivity in aircraft structural and engine alloys

, 1956
H. R. Voorhees, James W. Freeman
openalex   +1 more source

Precipitation of secondary Laves phases and its effect on notch sensitivity [PDF]

Weiwei Zhang, Yuanguo Tan, Yu Lai, Qi Chen, Yang Zhou   +4 more
openalex   +1 more source