Results 81 to 90 of about 14,144 (253)

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Cadernos escolares: como e o que se registra no contexto escolar?

Psicologia Escolar e Educacional
O presente artigo teve como objetivo problematizar um dos registros mais tradicionais do processo de escolarização: os cadernos escolares. Para tanto, a pesquisa explicita determinados aspectos relacionados à rotina de sala de aula, bem como descreve ...
Anabela Almeida Costa e Santos, Marilene Proença Rebello de Souza   +1 more
doaj  

Teachers' Pedagogical Reasoning and Students' Three‐Dimensional Learning

Science Education, EarlyView.
ABSTRACT This article reports analyses of data from a design‐based implementation project focused on middle‐ and high‐school science teaching. Drawing on teacher interviews and surveys as well as student learning evidence, we examined the relationships between teachers' pedagogical reasoning and their students' three‐dimensional learning. Most teachers
Christie Morrison Thomas, Beth A. Covitt, Qinyun Lin, Stefanie L. Marshall, James B. Hancock II, Charles W. Anderson   +5 more
wiley   +1 more source

Preserving Culinary Heritage Through AI: Sustainable Digitisation of Granny Josie’s Notebooks

Publications
Granny Josie’s Notebooks are salvaged notebooks written in 1946–1947 during a rural domestic science course for girls. This study aims to extract historically valuable information on the culinary heritage of post-war Poland and the housekeeping role ...
Karol Król, Maria Szkutak, Elżbieta Legutko   +2 more
doaj   +1 more source

Co‐Design to Capacity: An Instructional Design Approach for Indigenous Women Empowerment and Sustainable Technology Adoption

Sustainable Development, EarlyView.
ABSTRACT The adoption of rural livelihood technologies is often hindered by a gap between participatory design and user capacity. This study addresses this challenge with a co‐designed lemongrass distillation system in rural India that remained unused due to a lack of community capacity, despite a successful design process.
Aroun Clément Baudouin‐van Os, Raji Pushpalatha, Sruthy Sheela, Renjith Mohan, Maneesha Vinodini Ramesh   +4 more
wiley   +1 more source

Developing an interactive neuroimaging education resource with Neurodesk

Aperture Neuro
Neuroimaging education presents both conceptual and technical challenges: one must master complex foundational principles while navigating technical requirements including software installation, dependency management, and cross-platform compatibility ...
Monika Dörig, Michèle Masson-Trottier, Thuy T. Dao, Kyle Mapue, Andrew Jahn, Fernanda L. Ribeiro, Ashley Stewart, Thomas B. Shaw, Michal Toth, Marla Pinkert, Paul A. Taylor, Angela Renton, Daniel Handwerker, Giulia Baracchini, Christopher Rorden, Aswin Narayanan, Steffen Bollmann   +16 more
doaj   +1 more source

Advanced Hybrid Techniques for Cyberattack Detection and Defense in IoT Networks

SECURITY AND PRIVACY, Volume 8, Issue 2, March/April 2025.
ABSTRACT The Internet of Things (IoT) represents a vast network of devices connected to the Internet, making it easier for users to connect to modern technology. However, the complexity of these networks and the large volume of data pose significant challenges in protecting them from persistent cyberattacks, such as distributed denial‐of‐service (DDoS)
Zaed S. Mahdi, Rana M. Zaki, Laith Alzubaidi   +2 more
wiley   +1 more source