Results 151 to 160 of about 6,190,445 (297)

Un nou mètode per determinar la deformació dels conglomerats i les seves propietats materials

, 2018
Un grupo internacional de la Universidad alemana Tübingen en colaboración con el departamento de Geología de la UAB han publicado un estudio sobre los conglomerados depositados en los ríos de la China central hace un billón de años. Han descubierto un nuevo método para determinar la cantidad de deformación experimentada producida por periodos de ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Choosing Wisely Canada climate-conscious recommendations for critical care medicine. [PDF]

Can J Anaesth
Balan M, Bodley TF, Montazeripouragha A, Baharmand I, Yu ACM, Burns KEA, Murthy S, Canadian Critical Care Society (CCCS) and on behalf of the CCCS Choosing Wisely Canada Climate-Conscious Recommendations Working Group.   +7 more
europepmc   +1 more source

Exploració d'un format nou d'activitat matemàtica a l'educació secundària i creació i experimentació d'un recurs material

, 2014
The aim of this Project is to explore a new system to teach mathematics in “secondary education” and to create and work with a material resource with the purpose of sharing them with the educational community if they happen to be useful. A brief introduction is carried out, in order to place the reader in the subject. Personal motivations, the interest
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research. [PDF]

Can J Anaesth
Palermo TM, Bouhassira D, Davis KD, Hemmings HC, Hurley RW, Katz J, Pandit JJ, Price TJ, Schatman ME, Schwarz SKW, Turk DC, Van de Velde M, Wiles MD, Yaksh TL, Yarnitsky D.   +14 more
europepmc   +1 more source

Nous materials moleculars inorgànics basats en metal·lacarborans: Preparació, caracterització i anàlisi de propietats físico-químiques

, 2016
Aquesta tesi doctoral tracta de la derivatització de metal·lacarborans per obtenir nous materials moleculars per a possibles aplicacions en diferents camps de l’electrònica molecular. En aquest aspecte, s’han dissenyat nous mètodes de síntesi de derivats de metal·lacarborans amb diferents fragments orgànics, així com la optimització de mètodes ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

How are we preparing doctors for their roles as patient educators? Exploring undergraduate and postgraduate curricula in Canadian medical schools. [PDF]

Can Med Educ J
Cohen A, Gomez-Garibello C, Steinert Y.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source