Results 181 to 190 of about 38,174 (285)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Síntesi de nous catecols amb aplicació en materials adhesius bioinspirats

En el nostre grup de recerca i en col·laboració amb el doctor Daniel Ruiz-Molina del Centre d'Investigació en Nanociència i Nanotecnologia (CIN2) d'aquest campus universitari, hem iniciat un projecte que es planteja aconseguir biomimetitzar certes ...
Guardingo Melián, Mireia, Universitat Autònoma de Barcelona. Facultat de Ciències, Universitat Autònoma de Barcelona. Departament de Química   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Phenology and parasitism rates of Xenos oxyodontes and Xenos moutoni (Strepsiptera: Xenidae) in Vespa (Hymenoptera: Vespidae) in South Korea. [PDF]

Parasite
Kim J, Kim CJ, Choi MB, Kwon O.
europepmc   +1 more source

Un nou mètode per formar materials polimèrics amb llum millorarà la resolució de la impressió 3D

Las técnicas litográficas y de impresión 3D están limitadas por los largos tiempos de impresión o la baja resolución que impide llegar a escalas micrométricas. El Departamento de Química participa en el desarrollo de una técnica alternativa: el fotocurado de polímeros, que permite controlar la formación de polímeros mediante la irradiación con luz para
Marco, Arnau, Villabona, Marc, Guirado López, Gonzalo, Sebastián Pérez, Rosa Maria, Hernando Campos, Jordi   +4 more
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Gestion optimisée des intrants pour une réponse efficace en contexte de pandémie au Cameroun. [PDF]

J Public Health Afr
Fokam J, Abega Abega CA, Jagni Semengue EN, Abba A, Takou D, Beloumou GA, Djupsa Ndjeyep SC, Nka AD, Anguechia Gouissi DH, Ngwese Tambe DA, Collins C, Christelle Ka'e A, Tommo Tchouaket MC, Nayang Mundo RA, Kengni Ngueko AM, Etame NK, F Moko LG, Molimbou E, Togna Pabo WL, Patricia Tueguem P, Fainguem N, Mba LF, Yatchou LG, Ibnou N, Bienvenu Onana T, Boum Y, Etoundi Mballa AG, Ndjolo A.   +27 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

[Treatment of snakebites at the Guinea Institute for Applied Biology Research]. [PDF]

Med Trop Sante Int
Baldé O, Baldé MA, Baldé MC, Diallo MC, Traoré MS.   +4 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source