Results 231 to 240 of about 210,426 (300)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Re-evaluating the role of personal statements in pediatric residency admissions in the era of artificial intelligence: comparing faculty ratings of human and AI-generated statements. [PDF]

Can Med Educ J
Curry B, Kirpalani A, Remington M, Van Hooren T, Shen Y, Peebles ER.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Seasonal effects of farmer-managed livestock grazing exclusions on bird communities in Burkina Faso. [PDF]

Ecol Appl
Quintas I, Marcacci G, Zongo AN, Korner P, Kuttnig A, Spaar R, Diakité B, Kaguembèga-Müller F, Jacot A.   +8 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

[Evaluation of snakebite management cost at Saint Jean de Dieu Hospital in Tanguiéta, Benin]. [PDF]

Med Trop Sante Int
Tourita N, Sodjinou N, Ouorou SA, Ganhouingnon É, Massougbodji A, Chippaux JP, Larréché S.   +6 more
europepmc   +1 more source

Materials emergents: els nous materials entren al laboratori

, 2014
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A pilot randomized trial of a virtual perioperative smoking cessation bundle in a tertiary care hospital. [PDF]

Can J Surg
Pillar M, Sara R, Burditt D, Rai RK, Monteiro L, Lertnamvongwan R, Mozel M, Merchant R, Lee SM.   +8 more
europepmc   +1 more source