Results 31 to 40 of about 728,167 (238)

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

Improved access and care through the implementation of virtual Hallway, a consultation platform in Nova Scotia: preliminary findings from a feasibility evaluation

Implementation Science Communications
Background While previous studies have examined various platforms that enable providers to connect, Virtual Hallway (VH) stands out with its unique features.
Gail Tomblin Murphy, Tara Sampalli, Prosper Koto, Caroline Chamberland-Rowe, Julia Guk, Nelson Ventura, Justin Hartlen, Daniel Rasic, Jonathan Allen, Kianna Benson, Ryan MacNeil   +10 more
doaj   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

In This Together

International Journal of Qualitative Methods, 2017
This article explores what it means to engage youth in meaningful dissemination of research findings. To do so, the authors (a group of academic researchers and youth collaborators, aged 14–18) consider their experience working together on the Spaces ...
Jenny Reich, Linda Liebenberg, Mallery Denny, Hannah Battiste, Angelo Bernard, Kevin Christmas, Ronald Dennis, Dionne Denny, Ivan Knockwood, Raylene Nicholas, Hugh Paul   +10 more
doaj   +1 more source

Reproductive stages in lowbush blueberry (Vaccinium angustifolium) occur earlier with increasing temperature

American Journal of Botany, EarlyView.
Abstract Premise Climate change is altering the timing of many plant phenological events, yet most studies focus on flowering, with less attention given to later reproductive stages such as fruit development and ripening. Vaccinium angustifolium (lowbush blueberry) is an important perennial berry species that may be sensitive to these changes.
Jenna Floyd, Elise Cadiou, Alain G. Belliveau, Zoe A. Panchen, Terrell T. Roulston, Zoë Migicovsky   +5 more
wiley   +1 more source

Potentially Inappropriate Drug Duplication in a Cohort of Older Adults with Dementia

Current Therapeutic Research, 2021
: Background: Concurrent use of 2 nonsteroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, loop diuretics, angiotensin-converting enzyme inhibitors, or anticoagulants is considered potentially inappropriate by Screening Tool of ...
Shanna C. Trenaman, BScH, BScPharm, MAHSR, ACPR, PhD, Susan K. Bowles, PharmD, MSc, Susan A. Kirkland, PhD, Melissa K. Andrew, MD, MPH, PhD   +3 more
doaj   +1 more source

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The impact of presumptive coverage policies for work‐related mental health disorders has not been extensively studied to date. Using data from the Association of Workers’ Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensated mental health conditions, and to explore the association ...
Quentin Durand‐Moreau, Alexis Descatha, Anil Adisesh, Peter Smith   +3 more
wiley   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Understanding the uptake of virtual care for first and return outpatient appointments in child and adolescent mental health services: a mixed-methods study

BMJ Open, 2023
Objective To describe patterns of virtual and in-person outpatient mental health service use and factors that may influence the choice of modality in a child and adolescent service.Design A pragmatic mixed-methods approach using routinely collected ...
Leslie Anne Campbell, Sharon E Clark, Jill Chorney, Debbie Emberly, NJ Carrey, Alexa Bagnell, Jaime Blenus, Miriam Daneff, John Charles Campbell   +8 more
doaj   +1 more source

Integrating Genetic Modifier Genotype With Serum Proteomics in Duchenne Muscular Dystrophy Clinical Trials Links LTBP4 Genetic Modifier to IL‐23/CD93 Pathways in Muscle

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic modifiers of Duchenne muscular dystrophy (DMD) that alter disease severity or response to therapy have been reported using natural history or registry data sets of older corticosteroid‐treated patients. We tested associations of genetic modifiers on motor function outcomes in young (4 to < 7 years) steroid naïve clinical trial ...
Utkarsh J. Dang, Yuan Fang, Daniele Sabbatini, Elena Pegoraro, Luca Bello, Paula R. Clemens, Michela Guglieri, John van den Anker, Jesse Damsker, Laura Hagerty, Yetrib Hathout, Michael Ziemba, Lauren Morgenroth, Surajit Bhattacharya, Kanneboyina Nagaraju, Jyoti K. Jaiswal, Eric P. Hoffman   +16 more
wiley   +1 more source