Results 151 to 160 of about 17,241,247 (352)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Robust hierarchical federated learning with dual-layer filtering mechanism

International Journal of Advanced Robotic Systems
Hierarchical federated learning (HFL) is an effective “cloud-edge-device” distributed model training framework that protects data privacy. During HFL training, poisoning attacks on local data and transmitted models can affect the accuracy of the global ...
Chaoyi Yang, Wei Liang, Yuxiang Chen, Jiahong Xiao, Dacheng He, Tianxiong Liu, Jin Wang, Amr Tolba   +7 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

A large language model for deriving spectral embeddings for accurate compound identification in mass spectrometry

Communications Chemistry
Identifying chemical components in complex mixtures is a crucial task across many scientific disciplines. Mass spectrometry serves as a key analytical tool for this purpose, yet the accurate identification of compounds from their spectra remains a major ...
Yang Xu, Yixiao Ma, Weijie Xu, Zuliang Yang, Kai Ming Ting   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

High-Energy Burst-Mode 3.5 μm MIR KTA-OPO

Photonics
In this paper, a high energy 3.5 μm mid-infrared (MIR) burst-mode KTA optical parametric oscillator (OPO) was demonstrated. Utilizing a quasi-continuous wave (QCW) laser diode (LD) side-pump module and electro-optic (EO) Q-switching technique, a high ...
Haowen Guo, Chunyan Jia, Shuai Ye, Yongping Yao, Tiejun Ma, Jiayu Zhang, Meng Bai, Jinbao Xia, Hongkun Nie, Bo Yao, Jingliang He, Baitao Zhang   +11 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

EVALUASI PROGRAM PRAKTIKUM PENEMPATAN KLINIS DALAM PENGEMBANGAN KOMPETENSI PEDAGOGIK CALON GURU PAUD PADA FAKULTAS ILMU PENDIDIKAN UNIVERSITAS XYZ

Scholaria: Jurnal Pendidikan dan Kebudayaan
Pedagogical competence is one of the important competencies for teachers to have. As one of the LPTK that produces prospective teachers, XYZ University has a role in ensuring that its students achieve pedagogical competence by organizing the Clinical ...
Estahayati Sitompul, Novel Priyatna
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Influence of Superplasticizers on the Diffusion-Controlled Synthesis of Gypsum Crystals

Crystals
Gypsum (CaSO4·2H2O) crystallization underpins numerous industrial processes, yet its response to chemical admixtures remains incompletely understood. This study investigates diffusion-controlled crystal growth in a coaxial test tube system to evaluate ...
F. Kakar, C. Pritzel, T. Kowald, M. S. Killian   +3 more
doaj   +1 more source