Results 231 to 240 of about 7,018,409 (297)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Biomechanical analysis of a novel, triangular spinal fixation system. [PDF]

N Am Spine Soc J
Mazza J, Serbousek J, Fessler RG.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Expanding the Genetic Blueprint of Wilms Tumor: An Account of 71 Novel Variants across 16 Genes with Novel Implications for Wilms Tumor Pathogenesis.

J Indian Assoc Pediatr Surg
Kumar S, Sharma J, Pandey H, Jain V, Dhua AK, Yadav DK, Divya G, Lal D, Goel P, Agarwala S.   +9 more
europepmc   +1 more source

Identification of a potential novel <i>Staphylococcus</i> species via genomic sequencing: A neonatal infection case report. [PDF]

IDCases
Wei F, Wang X, Lv H, Xia H, Gan G, Chen X, Liu X, Chen H, Zhao L.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects. [PDF]

Nat Commun
Jia T, Peng YT, Sun YL, Yin C, Gu X, Yang L, Zhang S, Cao JL, Xiao C, Zhou C.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

<i>COCH</i>-Related Hearing Loss in a French Cohort: Novel Variants and Genotype-Phenotype Correlations. [PDF]

Genes (Basel)
Balogoun R, Serey-Gaut M, Pingault V, Lemiere I, Lina-Granade G, Delplancq G, Guerrot AM, Toutain A, Dupin-Deguine D, Legendre M, Colin E, Loundon N, Jonard L, Marlin S.   +13 more
europepmc   +1 more source

Novel biomimetic design for composite materials

, 2012
Luigi N.i.c.o.l.a.i.s. Novel biomimetic design for composite materials, Luisa Russo, BORZACCHIELLO, ASSUNTA, Maria Assunta Autiello   +3 more
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