Results 241 to 250 of about 1,069,421 (301)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Infertility Due to a Novel Variant of a Balanced Y;1 Translocation: A Case Report. [PDF]

Cureus
Magnuson S, Doney K, Wesemann LB, Gross K.   +3 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A Rare Disease and a Novel Variant in an Indian patient with Cerebellar Ataxia: A Case of Gordon Holmes Syndrome. [PDF]

Ann Indian Acad Neurol
Suhas VP, Sukrutha R, Prasad C, Arunachal G, Mahale R, Padmanabha H, Pavagada M, Mailankody P.   +7 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Vaccination with Lipid Nanoparticle-Delivered VP2-DNA Elicits Immune Protection in Chickens Against Novel Variant Infectious Bursal Disease Virus (nVarIBDV). [PDF]

Vaccines (Basel)
Zhang Y, Wu Z, Yu H, Wang G, Liu R, Ling D, Ke E, Liu X, Xu T, Wang S, Chen Y, Liu Y, Cui H, Zhang Y, Duan Y, Gao Y, Qi X.   +16 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Novel variant in <i>OTOG</i> gene in consanguineous family with sensorineural hearing loss. [PDF]

BMJ Case Rep
An Y, Chan D, Wallerstein R.
europepmc   +1 more source

Germline mutations of GCM2 cause a novel variant of hereditary primary hyperparathyroidism. [PDF]

Updates Surg
Iacobone M, Watutantrige-Fernando S, Zovato S, Tognazzo S, Dughiero S, Augenti V, Camozzi V, Mian C, Torresan F, Nomine-Criqui C, Brunaud L.   +10 more
europepmc   +1 more source

Stüve-Wiedemann syndrome with a novel variant in the LIFR gene: A case report. [PDF]

Medicine (Baltimore)
Sherbiny HS, Alfaifi JA, Ahmed AO, Hassan H, Abdullah R, Alsuwat SA, Al-Juaid RM, Neyaz AA, Oshi MAM, Kamal NM.   +9 more
europepmc   +1 more source