Results 111 to 120 of about 974,149 (336)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

GlassGaussian: Extending 3D Gaussian Splatting for Realistic Imperfections and Glass Materials

open access: yesIEEE Access
3D scene reconstruction methods have made significant advancements in handling reflections. However, these methods are primarily effective on ideal mirror surfaces, which limits their applicability in real-world scenarios where imperfections or materials
Junming Cao   +2 more
doaj   +1 more source

Unsupervised Learning of Depth and Ego-Motion from Video

open access: yes, 2017
We present an unsupervised learning framework for the task of monocular depth and camera motion estimation from unstructured video sequences. We achieve this by simultaneously training depth and camera pose estimation networks using the task of view ...
Brown, Matthew   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Li-GS: a fast 3D Gaussian reconstruction method assisted by LiDAR point clouds

open access: yesBig Earth Data
Digital twin technology, serving as a bridge between the physical and digital worlds, has demonstrated significant potential across various fields. In the domain of 3D reconstruction, recent advancements in Neural Radiance Fields (NeRF) and 3D Gaussian ...
Wenzhuo Chen   +3 more
doaj   +1 more source

Novel View Synthesis using DDIM Inversion

open access: yesCoRR
Synthesizing novel views from a single input image is a challenging task. It requires extrapolating the 3D structure of a scene while inferring details in occluded regions, and maintaining geometric consistency across viewpoints. Many existing methods must fine-tune large diffusion backbones using multiple views or train a diffusion model from scratch,
Singh, Sehajdeep   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Novel View Synthesis of Defocused Blur Scenes Based on Neural Radiance Fields

open access: yesIEEE Access
In recent years, neural radiance fields have been widely used in the field of computer graphics due to their excellent reconstruction quality. However, the shooting process in the wild environment is often affected by various internal and external ...
Zhaoji Lin, Yuxin Zheng, Li Yao
doaj   +1 more source

Why stakeholder and stockholder theories are not necessarily contradictory: A knightian insight [PDF]

open access: yes
The normative foundations of the investor centered model of corporate governance, represented in mainstream economics by the nexus-of-contracts view of the firm, have come under attack, mainly by proponents of normative stakeholder theory.
Velamuri, Rama, Venkataraman, Sankaran
core  

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