Results 101 to 110 of about 370,974 (275)

Into the Fray: Novice Teachers Tackle Standards-Based Mathematics [PDF]

open access: yes, 2007
This article tracks twenty-one graduates of a refom-based mathematics teacher education program for two years as they begin teaching mathematics in public elementary schools in New York City.
Gningue, S., Schroder, B.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Teachers' Training, Class Size and Students' Outcomes: Learning from Administrative Forecasting Mistakes [PDF]

open access: yes
This paper studies the impact of different teacher and class characteristics on third graders' outcomes. It uses a feature of the French system in which some novice teachers start their jobs before receiving any training. Three categories of teachers are
Bressoux, Pascal   +2 more
core  

Securing the Elderly: A Developmental Approach to Hypermedia-Based Online Information Security for Senior Novice Computer Users [PDF]

open access: yes, 2011
Whilst security threats to the general public continue to evolve, elderly computer users with limited skill and knowledge are left playing catch-up in an ever-widening gap in fundamental cyber-related comprehension.
Cook, David   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Applying virtual reality to sail education: an innovative strategy to enhance knowledge learning for student novices

open access: yesFrontiers in Psychology
BackgroundSailing has been proved beneficial for physical and mental health promotion, which has made it a prevalent sport among children and adolescents. Nevertheless, the existing pedagogical strategies cannot satisfy students’ demands for learning. To
Shan Zhao, Fa Ji, Fa Ji
doaj   +1 more source

Effect of novice driver’s car-following characteristic on roadway segment capacity

open access: yesAdvances in Mechanical Engineering, 2017
The presence of significant proportion of novice drivers greatly affects traffic flow performance due to their poor driving skills. The primary objective of this study was to develop adjustment factors to evaluate the impacts of novice driver’s car ...
Haifei Yang, Zhong Wu
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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