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ERK1/2 mitogen-activated protein kinase dimerization is essential for the regulation of cell motility. [PDF]

Mol Oncol
In mammary tumor cells, ERK dimerization is both necessary and sufficient for inducing cellular migration. The scaffold protein KSR1 is a critical element for endowing external agonists, acting through tyrosine kinase receptors, with the capacity to induce ERK dimerization and, subsequently, unleashing cellular motion, as a consequence of which tumor ...
de la Fuente-Vivas D +12 more
europepmc +2 more sources

Global anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study. [PDF]

Anaesthesia
Summary Introduction Restoration of surgical capacity is essential to post‐COVID‐19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.
NIHR Global Health Research Group on Environmentally Sustainable Hospitals in Low‐ and Middle‐income Countries.
europepmc +2 more sources

Targeting the central nervous system: From synthetic nanoparticles to extracellular vesicles—Focus on Alzheimer's and Parkinson's disease

WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 5, September/October 2023., 2023
Nanomedicine and neurodegenerative diseases. Abstract Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are an accelerating global health problem as life expectancy rises worldwide. Despite their significant burden in public health systems to date, the existing treatments only manage the symptoms without ...
Sara Hernando +3 more
wiley +1 more source

Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia

Alzheimer's &Dementia, Volume 19, Issue 5, Page 1947-1962, May 2023., 2023
Abstract Introduction We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site.
David J. Whiteside +157 more
wiley +1 more source

Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia

Human Brain Mapping, Volume 44, Issue 7, Page 2684-2700, May 2023., 2023
The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Voxel‐wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses were used to link morphometry and behavior.
Aurélie Bussy +166 more
wiley +1 more source

CSF glial markers are elevated in a subset of patients with genetic frontotemporal dementia

Annals of Clinical and Translational Neurology, Volume 9, Issue 11, Page 1764-1777, November 2022., 2022
Abstract Background Neuroinflammation has been shown to be an important pathophysiological disease mechanism in frontotemporal dementia (FTD). This includes activation of microglia, a process that can be measured in life through assaying different glia‐derived biomarkers in cerebrospinal fluid. However, only a few studies so far have taken place in FTD,
Ione O. C. Woollacott +152 more
wiley +1 more source

Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia

Alzheimer's &Dementia, Volume 18, Issue 7, Page 1408-1423, July 2022., 2022
Abstract The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear
Alberto Benussi +156 more
wiley +1 more source

Deep learning driven biosynthetic pathways navigation for natural products with BioNavi-NP

Nature Communications, 2022
The complete biosynthetic pathways are unknown for most natural products (NPs), it is thus valuable to make computer-aided bio-retrosynthesis predictions.
Shuangjia Zheng +6 more
semanticscholar +1 more source

The CBI‐R detects early behavioural impairment in genetic frontotemporal dementia

Annals of Clinical and Translational Neurology, Volume 9, Issue 5, Page 644-658, May 2022., 2022
Abstract Introduction Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at present. Methods We assessed behaviour using the revised version of the Cambridge Behavioural Inventory (CBI‐R) in 733 participants from the Genetic FTD Initiative study: 466 mutation ...
Annabel Nelson +155 more
wiley +1 more source

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy [PDF]

, 2015
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented.
Cronin, Leroy +3 more
core +2 more sources

computer science
mathematics
medicine

physics
horario universitario
optimización combinatoria

programación entera binaria
chemistry