Results 1 to 10 of about 130 (57)

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. [PDF]

PLoS Genetics, 2022
Mammalian hearing involves the mechanoelectrical transduction (MET) of sound-induced fluid waves in the cochlea. Essential to this process are the specialised sensory cochlear cells, the inner (IHCs) and outer hair cells (OHCs).
Sherylanne Newton, Fanbo Kong, Adam J Carlton, Carlos Aguilar, Andrew Parker, Gemma F Codner, Lydia Teboul, Sara Wells, Steve D M Brown, Walter Marcotti, Michael R Bowl   +10 more
doaj   +8 more sources

Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function. [PDF]

J Neurosci, 2016
Neuroplastin (Nptn) is a member of the Ig superfamily and is expressed in two isoforms, Np55 and Np65. Np65 regulates synaptic transmission but the function of Np55 is unknown. In an N-ethyl-N-nitrosaurea mutagenesis screen, we have now generated a mouse line with an Nptn mutation that causes deafness.
Zeng WZ, Grillet N, Dewey JB, Trouillet A, Krey JF, Barr-Gillespie PG, Oghalai JS, Müller U.   +7 more
europepmc   +4 more sources

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface. [PDF]

PLoS ONE, 2013
BackgroundThe neuroplastins np65 and np55 are two synapse-enriched immunoglobulin (Ig) superfamily adhesion molecules that contain 3 and 2 Ig domains respectively.
Marieangela C Wilson, Michaela Kraus, Hassan Marzban, Justyna R Sarna, Yisong Wang, Richard Hawkes, Andrew P Halestrap, Philip W Beesley   +7 more
doaj   +2 more sources

Ceruloplasmin‐deficient mice show changes in PTM profiles of proteins involved in messenger RNA processing and neuronal projections and synaptic processes

Journal of Neurochemistry, Volume 165, Issue 1, Page 76-94, April 2023., 2023
In humans, deficiency of the multicopper oxidase and ferroxidase Ceruloplasmin (Cp) leads to neurological symptoms. Proteomics analysis of forebrains from asymptomatic 4‐ to 6‐month‐old Cp‐deficient mice identified >5600 proteins whereof 23 were regulated, and >1200 proteins had regulated post translational modifications, including sialylation of ...
Birgitte Villadsen, Camilla Thygesen, Manuela Grebing, Stefan J. Kempf, Marie B. Sandberg, Pia Jensen, Stefanie H. Kolstrup, Helle H. Nielsen, Martin R. Larsen, Bente Finsen   +9 more
wiley   +1 more source

Comercio Exterior - NP55 - 202102

, 2021
Descripción: Curso teórico-práctico que permitirá al estudiante articular los fundamentos de la Gestión operativa y estratégica del comercio exterior. Propósito: El curso ha sido diseñado para que la información adquirida se transforme posteriormente en posibilidades estratégicas para la toma de decisiones, no tiene ningún curso como pre-requisito y ...
Blas Rivera, Aldrudover, Guillén Málaga, Luis Gonzalo, Hinostroza Chuco, Geraldine Rosmeri, Quevedo Saavedra, Carlos Armando, Zorrilla Morris, Paula Mayra Jackeline   +4 more
openaire   +1 more source

Comercio Exterior - NP55 - 202101

, 2021
Descripción: Curso teórico-práctico que permitirá al estudiante articular los fundamentos de la Gestión operativa y estratégica del comercio exterior. Propósito: El curso ha sido diseñado para que la información adquirida se transforme posteriormente en posibilidades estratégicas para la toma de decisiones, no tiene ningún curso como pre-requisito y ...
Guillén Málaga, Luis Gonzalo, Pacheco Infante, Danny William, Zorrilla Morris, Paula Mayra Jackeline   +2 more
openaire   +1 more source

Plasma membrane Ca2+ pump isoform 4 function in cell migration and cancer metastasis

The Journal of Physiology, Volume 602, Issue 8, Page 1551-1564, 15 April 2024.
Abstract figure legend Plasma membrane Ca2+ ATPases (PMCAs) are key regulators of low cytosolic Ca2+ concentration in mammalian cells. In cancer, dysregulation of Ca2+ homeostasis is involved in cell migration and metastasis. Transcription, expression, localization, trafficking and activity of the PMCA4 isoform are reported to vary in different cancer ...
Randa Naffa, Luca Hegedűs, Tamás Hegedűs, Sarolta Tóth, Béla Papp, Attila Tordai, Ágnes Enyedi   +6 more
wiley   +1 more source

De novo variants in NPTN cause a neurodevelopmental disorder with autism and neuroplastin-PMCA hypofunction

Genome Medicine
Background NPTN encodes human neuroplastin (hNp), a transmembrane immunoglobulin (Ig)-superfamily glycoprotein and a subunit of the plasma membrane calcium (Ca2+)-ATPases (PMCA).
Yi Liang, Rodrigo Ormazabal-Toledo, Harini Srinivasan, Ayse Malci, Waldo Acevedo, Ulrich Thomas, Julie S. Cohen, Nils Rahner, Johannes Luppe, Gabriella Vera, Francois Lecoquierre, Eden Kroin, Brad Angle, Hong Cui, Maria J. Guillen Sacoto, Bert B. A. de Vries, Rolph Pfundt, Gillian Prinzing, Kimberly Wiltrout, Yakira Begun, Elaine M. Pereira, Alexandra Afenjar, Caroline Nava, Konrad Platzer, Dirk Montag, Rodrigo Herrera-Molina   +25 more
doaj   +1 more source

Comercio Exterior - NP55 - 202100

, 2021
Descripción: Curso electivo de la carrera de Administración teórico-práctico dirigido a los estudiantes del 6to ciclo, el curso de Comercio exterior en la carrera de Negocios Internacionales te permitirá articular los fundamentos de la Gestión operativa y estratégica del comercio exterior.
openaire   +1 more source

Neuroplastin in Ca²⁺ signal regulation and plasticity of glutamatergic synapses. [PDF]

Neural Regen Res, 2023
Malci A, Lin X, Shi YS, Herrera-Molina R.   +3 more
europepmc   +1 more source