Results 51 to 60 of about 8,831 (201)

Stability of NPR1 and NPR2 in the presence of the NPR1 paralogs.

, 2018
(a) Stability of GFP-NPR1 when co-expressed with the NPR1 paralogs fused to MBP. The constructs were agroinfiltrated with 1mM SA treatment one day before sampling. (b) Stability of GFP-NPR2 when co-expressed with the NPR1 paralogs, as in (a).
Pablo Tornero (125801), Laura Medina-Puche (4284865), Julián Lamilla (4284862), María José Castelló (530455)   +3 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

The expression of the NPR1-dependent defense response pathway genes in Persea americana (Mill.) following infection with Phytophthora cinnamomi

BMC Plant Biology, 2023
A plant’s defense against pathogens involves an extensive set of phytohormone regulated defense signaling pathways. The salicylic acid (SA)-signaling pathway is one of the most well-studied in plant defense. The bulk of SA-related defense gene expression
Robert Backer, Sanushka Naidoo, Noëlani van den Berg   +2 more
doaj   +1 more source

Investigating the role of NPR1 in dilated cardiomyopathy and its potential as a therapeutic target for glucocorticoid therapy

Frontiers in Pharmacology, 2023
Background: Dilated cardiomyopathy (DCM), a specific form of cardiomyopathy, frequently presents clinically with either left ventricular or biventricular enlargement, often leading to progressive heart failure.
Yaomeng Huang, Tongxin Li, Shichao Gao, Shuyu Li, Xiaoran Zhu, Ying Li, Dangyang Liu, Weimin Li, Linquan Yang, Kunshen Liu, Zheng Zhang, Chao Liu   +11 more
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

The NPR1 ortholog PhaNPR1 is required for the induction of PhaPR1 in Phalaenopsis aphrodite [PDF]

Botanical Studies, 2013
Abstract Background Systematic acquired resistance (SAR) is an effective broad-spectrum defense mechanism that confers long-lasting protection against biotrophic pathogens trough defense related salicylic acid (SA) signaling.
Chen, Jen-Chih, Lu, Hsiang-Chia, Chen, Cheng-En, Hsu, Hua-Fang, Chen, Hong-Hwa, Yeh, Hsin-Hung   +5 more
openaire   +2 more sources

RING E3 ligase SNIPER8 functions redundantly with three close homologs to regulate the turnover of transcriptional co‐repressor TPR1

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis E3 ligase SNIPER8 negatively regulates immunity by promoting ubiquitination and proteasomal degradation of the transcriptional corepressor TOPLESS‐RELATED1, limiting excessive immune responses, maintaining immune homeostasis, and balancing defense activation and normal plant growth.
Xueru Liu, Paul Kapos, Zhongshou Wu, Yujun Peng, Meixuezi Tong, Asana Khajavi, Yan Huang, Yuelin Zhang, Xin Li   +8 more
wiley   +1 more source

The Arabidopsis NPR1 Protein Is a Receptor for the Plant Defense Hormone Salicylic Acid

Cell Reports, 2012
Salicylic acid (SA) is an essential hormone in plant immunity, but its receptor has remained elusive for decades. The transcriptional coregulator NPR1 is central to the activation of SA-dependent defense genes, and we previously found that Cys521 and ...
Yue Wu, Di Zhang, Jee Yan Chu, Patrick Boyle, Yong Wang, Ian D. Brindle, Vincenzo De Luca, Charles Després   +7 more
doaj   +1 more source

Research progress of NPR genes in signal pathway of salicylic acid mediated plant disease resistance [PDF]

E3S Web of Conferences, 2020
Salicylic acid (SA) is considered to be an endogenous signal molecule in plants, and it is related to many resistances in plants. In Arabidopsis, Non-expressor of pathogenesis-related gene1 (NPR1) mediates the expression of pathogenesis-related genes ...
Wang Pan, Xiang Meiqin
doaj   +1 more source

Phosphorylation and Nuclear Localization of NPR1 in Systemic Acquired Resistance [PDF]

The Plant Cell, 2015
When plants sense a pathogen attack, they activate defenses in the immediate area and in distal tissues; this systemic acquired resistance (SAR) requires salicylic acid (SA), which activates NONEXPRESSER OF PATHOGENESIS-RELATED GENES1 (NPR1) in Arabidopsis thaliana (reviewed in [Fu and Dong, 2013 ...
openaire   +2 more sources