Results 81 to 90 of about 8,831 (201)
NPR1 inhibitors: new drugs for itch treatment?
Journal of Xiangya Medicine, 2019 In this issue of Science Translational Medicine , Solinski et al . (2019) (1) reported that pharmacological blockade of natriuretic peptide receptor 1 (NPR1), a receptor of neuropeptide natriuretic polypeptide b (NPPB), expressed by a subpopulation of mouse and human spinal cord neurons, may be the key to alleviate chronic itching.
Liang Cao, Lixia Du, Hongzhen Hu
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The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
Frontiers in Plant Science, 2015 Salicylic acid (SA) is a mandatory plant metabolite in the deployment of systemic acquired resistance (SAR), a broad-spectrum systemic immune response induced by local inoculation with avirulent pathogens.
Xiahezi eKuai +2 more
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Plants, 2020 The nonexpressor of pathogenesis-related 1 (NPR1) family plays diverse roles in gene regulation in the defense and development signaling pathways in plants.
Neha Agarwal +5 more
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Arabidopsis clade I TGA factors regulate apoplastic defences against the bacterial pathogen Pseudomonas syringae through endoplasmic reticulum-based processes. [PDF]
PLoS ONE, 2013 During the plant immune response, large-scale transcriptional reprogramming is modulated by numerous transcription (co) factors. The Arabidopsis basic leucine zipper transcription factors TGA1 and TGA4, which comprise the clade I TGA factors, have been ...
Lipu Wang, Pierre R Fobert
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Low level of polymorphism in two putative NPR1 homologs in the Vitaceae family [PDF]
Biology Direct, 2010 Grapevine is subjected to numerous pests and diseases resulting in the use of phytochemicals in large quantities. The will to decrease the use of phytochemicals leads to attempts to find alternative strategies, implying knowledge of defence mechanisms.
Bergeault, Karine +3 more
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British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub +3 more
wiley +1 more source
NPR1-Independent Activation of Immediate Early Salicylic Acid-Responsive Genes in Arabidopsis
Molecular Plant-Microbe Interactions, 2004 Salicylic acid (SA) is a key signal for the activation of defense genes in response to stress. The activation of late defense genes by SA, such as PR-1, involves the participation of the NPR1 protein.
Carolina Uquillas +4 more
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, 2018 Plant immunity depends on massive expression of pathogenesis-related genes (PRs) whose transcription is de-repressed by pathogen-induced signals. Salicylic acid (SA) acts as a major signaling molecule in plant immunity and systemic acquired resistance ...
Kang, Min-Jeong +7 more
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Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2821-2855, November 2026.Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley +1 more source